Isoprostanes in dystrophinopathy: Evidence of increased oxidative stress

Brain & Development
Salvatore GrossoGiuseppe Buonocore

Abstract

Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD) are degenerative disorders of muscle. Although the mechanisms underlying muscle degeneration are still uncertain, oxidative-damage has been proposed to play a key role. Isoprostanes are markers of free radical-catalyzed lipid peroxidation; the aim of our study was to evaluate plasma isoprostane levels in group of patients affected by Duchenne and Becker muscular dystrophies. PF(2)-isoprostane levels were measured by colorimetric enzyme immunoassay in the plasma of 17 patients with DMD and 24 with BMD. When compared to a group of healthy controls, affected patients showed significantly higher plasma levels of isoprostanes (p=0.001). When patients were stratified according to the clinical diagnosis, isoprostane levels were not statistically different between DMD and BMD patients. In conclusion whether the condition of oxidative stress found in plasma depends on the degenerative process occurring in muscles or on different mechanisms, such as the release of myoglobin in the blood, should be ascertained. However, our study confirms that oxidative stress findings in DMD/BMD patients are effectively present at the plasma levels. The condition of oxidative stress mi...Continue Reading

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Citations

Dec 7, 2013·Biogerontology·Hatice TohmaPeter G Arthur
Mar 13, 2014·Journal of Muscle Research and Cell Motility·Marcella CantonFabio Di Lisa
Oct 12, 2010·Journal of the Neurological Sciences·Salvatore GrossoGiuseppe Buonocore
Mar 16, 2011·Muscle & Nerve·Chad D MarkertRobert W Grange
May 11, 2016·Trends in Molecular Medicine·Natasha C ChangMichael A Rudnicki
Mar 27, 2019·Cells·John G Geisler
Oct 31, 2019·Journal of the American Heart Association·James D WestErica J Carrier
Jul 1, 2020·Animals : an Open Access Journal From MDPI·Magdalena OgłuszkaMariusz Pierzchała
May 29, 2021·American Journal of Physiology. Heart and Circulatory Physiology·R MitchellP Bagher
Aug 20, 2021·Transgenic Research·M I ZaynitdinovaS A Smirnikhina

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