Isoprostanoids in Clinical and Experimental Neurological Disease Models

Antioxidants
Cinzia SignoriniJetty Chung-Yung Lee

Abstract

Isoprostanoids are a large family of compounds derived from non-enzymatic oxidation of polyunsaturated fatty acids (PUFAs). Unlike other oxidative stress biomarkers, they provide unique information on the precursor of the targeted PUFA. Although they were discovered about a quarter of century ago, the knowledge on the role of key isoprostanoids in the pathogenesis of experimental and human disease models remains limited. This is mainly due to the limited availability of highly purified molecules to be used as a reference standard in the identification of biological samples. The accurate knowledge on their biological relevance is the critical step that could be translated from some mere technical/industrial advances into a reliable biological disease marker which is helpful in deciphering the oxidative stress puzzle related to neurological disorders. Recent research indicates the value of isoprostanoids in predicting the clinical presentation and evolution of the neurological diseases. This review focuses on the relevance of isoprostanoids as mediators and potential biomarkers in neurological diseases, a heterogeneous family ranging from rare brain diseases to major health conditions that could have worldwide socioeconomic impac...Continue Reading

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Citations

Feb 20, 2019·Antioxidants·Jetty Chung-Yung Lee, Thierry Durand
Jan 19, 2021·Journal of Oral and Maxillofacial Pathology : JOMFP·S MeeraK Rajkumar
Feb 10, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Libia Alejandra García-Flores, Cara L Green
May 1, 2021·International Journal of Molecular Sciences·Cinzia SignoriniClaudio De Felice

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