Isoproterenol-induced cardiac ischemia and fibrosis: Plant-based approaches for intervention

Phytotherapy Research : PTR
Prince AllawadhiChandraiah Godugu

Abstract

Heart is the most active and incumbent organ of the body, which maintains blood flow, but due to various pathological reasons, several acute and chronic cardiac complications arise out of which myocardial infarction is one of the teething problems. Isoproterenol (ISP)-induced myocardial ischemia is a classical model to screen the cardioprotective effects of various pharmacological interventions. Phytochemicals present a novel option for treating various human maladies including those of the heart. A large number of plant products and their active ingredients have been screened for efficacy in ameliorating ISP-induced myocardial ischemia including coriander, curcumin, Momordica, quercetin, and Withania somnifera. These phytochemicals constituents may play key role in preventing disease and help in cardiac remodeling. Reactive oxygen species scavenging, antiinflammatory, and modulation of various molecular pathways such as Nrf2, NFкB, p-21 activated kinase 1 (PAK1), and p-smad2/3 signaling modulation have been implicated behind the claimed protection. In this review, we have provided a focused overview on the utility of ISP-induced cardiotoxicity, myocardial ischemia, and cardiac fibrosis for preclinical research. In addition, we...Continue Reading

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Citations

Jul 31, 2019·Phytotherapy Research : PTR·Alessandra DurazzoAntonello Santini
Feb 23, 2020·Phytotherapy Research : PTR·Angelo A Izzo
Dec 7, 2018·Nanomedicine·Chandraiah GoduguAmit Khurana
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Dec 4, 2019·The American Journal of Chinese Medicine·Yonghui YuChenglong Wang
Mar 1, 2020·International Journal of Molecular Sciences·Kristina FerenczyovaMonika Bartekova
Jan 14, 2021·Critical Reviews in Food Science and Nutrition·Yue WangChong-De Sun
Mar 6, 2021·Naunyn-Schmiedeberg's Archives of Pharmacology·Fatemeh YarmohammadiGholamreza Karimi
Mar 11, 2021·Oxidative Medicine and Cellular Longevity·Shasha YuLilach O Lerman
Oct 15, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bingyan YangYu Zhang
Jun 8, 2021·Medical Hypotheses·Prince AllawadhiKala Kumar Bharani
Feb 25, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Lakshmi Priya PasariChandraiah Godugu

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