Isoproterenol infusion stress two-dimensional echocardiography in diagnosis of coronary artery disease in elderly patients. Comparison with the other stress testing methods

Japanese Heart Journal
T FujitaM Akisada

Abstract

Since a dynamic exercise stress test cannot always be performed adequately in elderly patients, an alternative method is needed for evaluation of coronary reserve. We studied two-dimensional echocardiographic (2-DE) and electrocardiographic (ECG) responses to infusion of isoproterenol (ISP) at a rate of 0.02 micrograms/Kg/min in 40 elderly patients with chest pain. The results were compared with exercise ECG (EX-ECG) tests and exercise radionuclide angiocardiography (EX-RNA) in 13 of these patients. No serious complications were encountered in the ISP test. The diagnostic sensitivity for coronary artery disease (CAD) was 71% for ISP-2-DE, 71% for ISP-ECG, 86% for EX-ECG and 71% for EX-RNA. The specificity for CAD was 83% for ISP-2-DE, 33% for ISP-ECG, 50% for EX-ECG and 100% for EX-RNA. In conclusion, the ISP-2-DE test is a safe, easily available and useful method for the assessment of coronary artery disease in elderly patients.

Citations

Nov 15, 1991·Journal of the American College of Cardiology·D J PennellP J Ell
Jun 1, 1996·Journal of the American College of Cardiology·P AbeteF Rengo
Jul 1, 1992·The American Journal of Cardiology·D J PennellD B Longmore
Dec 10, 1991·Echocardiography·J S Child
Feb 8, 1992·Echocardiography·S G SawadaH Feigenbaum
Dec 27, 2008·Circulation Journal : Official Journal of the Japanese Circulation Society·Masaaki Takeuchi, Yutaka Otsuji

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