Isoquinoline Alkaloids from Fumaria officinalis L. and Their Biological Activities Related to Alzheimer's Disease

Chemistry & Biodiversity
Jakub ChlebekLucie Cahlíková

Abstract

Two new isoquinoline alkaloids, named fumaranine (2) and fumarostrejdine (10), along with 18 known alkaloids were isolated from aerial parts of Fumaria officinalis. The structures of the isolated compounds were elucidated on the basis of spectroscopic analyses and by comparison with literature data. The absolute configuration of the new compound 2 was determined by comparing its circular dichroism spectra with those of known analogs. Compounds isolated in sufficient amounts were evaluated for their acetylcholinesterase, butyrylcholinesterase, prolyl oligopeptidase (POP), and glycogen synthase kinase-3β inhibitory activities. Parfumidine (8) and sinactine (15) exhibited potent POP inhibition activities (IC50 99±5 and 53±2 μM, resp.).

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Citations

Jul 9, 2016·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Noureddine BribiJulio Gálvez
Apr 20, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ramona PăltineanOvidiu Crișan
Jul 15, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tomáš SiatkaJakub Chlebek
Jul 22, 2017·Drug Testing and Analysis·Tiziana NardinRoberto Larcher
May 23, 2020·International Journal of Molecular Sciences·Juan Luis Fernández-MartínezAndrzej Kloczkowski
Jul 31, 2020·Medicinal Research Reviews·Xiao-Fei ShangKuo-Hsiung Lee
Feb 21, 2019·Journal of Medicinal Chemistry·Silvia StotaniSimona Collina

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