PMID: 6977015Sep 1, 1981Paper

Isotonic contraction of skinned muscle fibers on a slow time base: effects of ionic strength and calcium

The Journal of General Physiology
J Gulati, R J Podolsky

Abstract

The force development by calcium-activated skinned frog skeletal muscle fibers and the motion on a slow time base after a quick decrease in load were studied at 0-1 degrees C as a function of the ionic strength and the degree of activation. The ionic strength was varied between 50 and 190 mM by adding appropriate concentrations of KCl to the bathing solution. Under these conditions, the fibers could be maximally activated for several cycles at low ionic strength without developing residual tension. We found that the steady isometric force in fully activated fibers linearly decreased when the KCl concentration was increased from 0 to 140 mM. The steady isotonic motion at a given relative load in fully activated fibers was almost the same at KCl concentration greater than or equal to 50 mM. In 0 and 20 mM KCl, the isotonic velocity decreased continuously for more than 300 ms. At a given relative load, the initial velocity of the motion in 0 and 20 mM KCl was about 0.6 and 0.9 times, respectively, that in 140 mM KCl. The initial velocity decreased further when residual tension developed; this observation provides additional evidence that residual tension may reflect the presence of an internal load. The effect of calcium on the mo...Continue Reading

Citations

Oct 1, 1988·Pflügers Archiv : European journal of physiology·J D Altringham, I A Johnston
Oct 1, 1982·Acta Physiologica Scandinavica·M C Ekelund, K A Edman
Dec 8, 2005·Canadian Journal of Physiology and Pharmacology·Lincoln E Ford
May 6, 2003·The Journal of Physiology·Carl A MorrisEarl Homsher
Jun 1, 1983·Journal of Muscle Research and Cell Motility·R A Podolin, L E Ford
Jun 1, 1988·Journal of Muscle Research and Cell Motility·A J FarrowJ Unsworth
Jun 5, 1998·The American Journal of Physiology·P A WahrJ A Rall
Apr 1, 1983·Pflügers Archiv : European journal of physiology·A Arner
Sep 8, 1998·Journal of Applied Physiology·M P SlawnychB H Bressler
Oct 1, 1987·Journal of Muscle Research and Cell Motility·P Haugen
Oct 1, 1984·Journal of Muscle Research and Cell Motility·V Lombardi, G Menchetti
Aug 1, 1990·The American Journal of Physiology·H L GranzierG H Pollack
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Mar 1, 1992·The American Journal of Physiology·E HomsherJ R Sellers

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