Isotope-Edited Infrared Spectroscopy for Efficient Discrimination between Pharmaceutical Salts and Cocrystals

Molecular Pharmaceutics
Kentaro IwataYukihiro Ikeda

Abstract

Isotope-edited infrared spectroscopy using carboxylic acids selectively labeled with 13C is proposed herein for the efficient discrimination of pharmaceutical salts and cocrystals, whereby proton-transfer probe vibrations are highlighted by isotope shifts. This new technique can accurately discriminate even a confusing salt from a cocrystal for the traditional method, highlighting the diagnostic peaks. In addition, the established technique also provided the OH in-plane bending vibrations corresponding to intermolecular hydrogen bonding at the carbonyl oxygens of the cocrystals. The technique will accelerate the discrimination, which is a critical process in cocrystal development.

References

Jan 1, 1992·Journal of Pharmaceutical and Biomedical Analysis·K SagarR Munden
Jan 1, 1989·Mycoses·J HeykantsG Cauwenbergh
Jul 10, 2003·Journal of the American Chemical Society·Julius F RemenarOrn Almarsson
May 12, 2005·Advanced Drug Delivery Reviews·Siegfried Wartewig, Reinhard H H Neubert
Apr 28, 2007·Molecular Pharmaceutics·Scott L ChildsAeri Park
May 15, 2007·Molecular Pharmaceutics·Christer B AakeröyJohn Desper
Apr 5, 2008·Bulletin of Environmental Contamination and Toxicology·Jeong-Wook Kwon, Kevin L Armbrust
Jun 9, 2009·Crystal Growth & Design·Nate Schultheiss, Ann Newman
Sep 17, 2010·Journal of Pharmaceutical Sciences·Joanna S StevensSven L M Schroeder
Dec 1, 1986·Pharmaceutical Research·P Tyle
Mar 27, 2015·Journal of Pharmaceutical and Biomedical Analysis·Felipe T MartinsJavier Ellena
Nov 14, 2015·Chemical Communications : Chem Comm·Naga K DuggiralaMichael J Zaworotko

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Citations

Aug 25, 2020·Acta Crystallographica Section B, Structural Science, Crystal Engineering and Materials·Bo PengXuefeng Mei

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