Isotope metallomics approaches for medical research

Cellular and Molecular Life Sciences : CMLS
Brandon MahanSimon Turner

Abstract

Metallomics is a rapidly evolving field of bio-metal research that integrates techniques and perspectives from other "-omics" sciences (e.g. genomics, proteomics) and from research vocations further afield. Perhaps the most esoteric of this latter category has been the recent coupling of biomedicine with element and isotope geochemistry, commonly referred to as isotope metallomics. Over the course of less than two decades, isotope metallomics has produced numerous benchmark studies highlighting the use of stable metal isotope distribution in developing disease diagnostics-e.g. cancer, neurodegeneration, osteoporosis-as well as their utility in deciphering the underlying mechanisms of such diseases. These pioneering works indicate an enormous wealth of potential and provide a call to action for researchers to combine and leverage expertise and resources to create a clear and meaningful path forward. Doing so with efficacy and impact will require not only building on existing research, but also broadening collaborative networks, bolstering and deepening cross-disciplinary channels, and establishing unified and realizable objectives. The aim of this review is to briefly summarize the field and its underpinnings, provide a director...Continue Reading

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Citations

Oct 22, 2020·Metallomics : Integrated Biometal Science·Brandon MahanFrédéric Moynier
Nov 21, 2020·International Journal of Molecular Sciences·Yan ZhangLin Zheng

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Methods Mentioned

BETA
X-ray
imaging technique
ion exchange chromatography
IEC
imaging techniques

Software Mentioned

PIEC
SGIEC
Metallomics
GIEC
VIEC

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