Isotretinoin effect on alveolar repair after exodontia--a study in rats.

Oral and Maxillofacial Surgery
Roberta Dalmolin BergoliDaniela Nascimento Silva

Abstract

To evaluate isotretinoin effect on alveolar repair after tooth extraction of maxillary incisor and serum calcium levels in rats. Wistar rats (60-day-old) were assigned to control (CG, n = 12) and experimental (EG, n = 20) groups. EG received daily isotretinoin (7.5 mg/kg) for 30 days before surgery and until euthanasia, 7, 21, 28, or 90 days after tooth extraction. Blood was collected in the EG to analyze serum calcium levels before isotretinoin administration and at euthanasia. Right hemimaxillae underwent histological examination, and the slides were stained with HE and analyzed by descriptive light microscopy. There was acceleration in the process of alveolar repair in the EG at all time points when compared to controls. Serum calcium levels showed a statistically significant decrease between first and second blood collection at days 21, 28, and 90. Daily isotretinoin in a dose corresponding to the treatment of cystic acne accelerated alveolar repair.

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Citations

Dec 22, 2015·Aesthetic Plastic Surgery·Luís Fernando UngarelliJayme Adriano Farina Junior
Apr 25, 2013·Journal of Endodontics·Carlos Frederico B WolleMaria M Campos
Jan 17, 2012·Journal of Endodontics·Carlos Frederico Brilhante WolleMaria Martha Campos
Jan 1, 2013·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Henrique T R de OliveiraDaniela N Silva
May 13, 2017·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Abigail WaldmanMurad Alam
Jan 23, 2020·Journal of Orofacial Orthopedics = Fortschritte Der Kieferorthopädie : Organ/official Journal Deutsche Gesellschaft Für Kieferorthopädie·Musa BulutSevilay Erimsah
Jan 4, 2021·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·Ariane Ximenes Graciano ParraElisa Souza Camargo

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