Isotretinoin effects on bone

Journal of the American Academy of Dermatology
John J Digiovanna

Abstract

Isotretinoin has demonstrated efficacy in a wide range of disorders. The beneficial effects of the drug, however, are limited by its adverse effects on the bone. Children exposed to high doses are at risk for premature epiphyseal closure, while adults on long-term therapy have an increased tendency to develop hyperstosis and other changes of the bone. The knowledge of these effects, in conjunction with continued surveillance, are necessary for expert management and can ensure many years of efficacious treatment with minimal toxicity.

Citations

Apr 5, 2005·Pediatric Dermatology·Cheryl J BarnesBari B Cunningham
Aug 3, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·AeRang KimBrigitte C Widemann
Jan 10, 2008·Arthritis Research & Therapy·Jason S RockelSuzanne M Bernier
Dec 30, 2009·Journal of Dermatological Case Reports·Zoi ApallaGeorge Chaidemenos
Apr 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·Janet R Sparrow
Mar 18, 2015·Iranian Journal of Radiology : a Quarterly Journal Published by the Iranian Radiological Society·Adam Domonkos TarnokiViktor Berczi
Dec 22, 2015·Aesthetic Plastic Surgery·Luís Fernando UngarelliJayme Adriano Farina Junior
Jul 16, 2008·Expert Opinion on Drug Metabolism & Toxicology·Mei-Lin PangJohn Koo
Feb 16, 2005·Expert Opinion on Drug Safety·JoEllen Van Zander, Seth J Orlow
Dec 14, 2011·Joint, Bone, Spine : Revue Du Rhumatisme·François LuthiNicolas Theumann
Oct 22, 2011·Clinics in Dermatology·Elie B Lowenstein, Eve J Lowenstein
Jul 1, 2010·Medical Journal, Armed Forces India·A Kumar, V K Kumar
Sep 13, 2008·Seminars in Cutaneous Medicine and Surgery·Megan Brelsford, Trisha Clarke Beute
Jun 15, 2005·Dermatologic Therapy·Tor Shwayder, Tom Akland
May 30, 2003·The Journal of Dermatology·Kabir Sardana, Virendra N Sehgal
Aug 20, 2009·Pediatric Dermatology·C AntoniouA D Katsambas
May 15, 2008·International Journal of Dermatology·Nilgun Solak TekinSelda Isik Keskin
Oct 4, 2006·Dermatologic Therapy·Anja ThielitzHarald Gollnick
Feb 7, 2013·Dermatologic Therapy·John J DigiovannaJorge R Toro
Jan 3, 2013·Pediatric Dermatology·Iben Marie MillerGregor Borut Ernst Jemec
Apr 2, 2008·Expert Opinion on Pharmacotherapy·Klaus Degitz, Falk Ochsendorf
May 14, 2008·Expert Opinion on Pharmacotherapy·Marko Lens, Ljiljana Medenica
Jul 6, 2014·Clinical Rheumatology·Mustafa Turgut YıldızgörenTimur Ekiz
Jan 1, 2013·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Henrique T R de OliveiraDaniela N Silva
Mar 10, 2017·European Journal of Endocrinology·Edoarda V A AlbuquerqueAlexander A L Jorge
Aug 14, 2008·Clinical Pediatrics·Wynnis L Tom, Sheila Fallon Friedlander
Jun 8, 2002·Pharmacoepidemiology and Drug Safety
Sep 19, 2003·Rheumatology International·Ayçe AtalayYeşim Gökçe Kutsal
Jan 30, 2003·American Journal of Clinical Dermatology·John J DiGiovanna, Leslie Robinson-Bostom
Jul 27, 2010·Oral and Maxillofacial Surgery·Roberta Dalmolin BergoliDaniela Nascimento Silva
Jan 17, 2017·Polish Journal of Veterinary Sciences·M M Abd El-TawabN D Giadinis
Jul 10, 2018·The Journal of Clinical Endocrinology and Metabolism·Charles A SklarM Hassan Murad
Nov 20, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·I LuchsingerM Theiler
Jul 20, 2011·Current Opinion in Supportive and Palliative Care·Rebecca Silbermann, G David Roodman
Oct 19, 2007·The Cochrane Database of Systematic Reviews·F Bath-HextallW Perkins
Jun 25, 2015·JAAPA : Official Journal of the American Academy of Physician Assistants·Bridget K Reilly, Tamara S Ritsema

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