Isotretinoin induced achilles tendinopathy: Histopathological and biomechanical evaluation on rats

Acta orthopaedica et traumatologica turcica
Ozan BeytemurAkif Güleç

Abstract

The aim of the present study was to evaluate histopathological and biomechanical effects of isotretinoin on Achilles tendon. Sixteen rats were divided into two groups including the control group (n = 8) and isotretinoin group (n = 8). The control group received 1.42 ml/kg soy oil per day whereas the isotretinoin group received 15 mg/kg/day (gavage dose 1.42 ml/kg) isotretinoin dissolved in soy oil through gavage method for 6 weeks. Achilles tendons were excised at the end of week 6. The tendon samples were evaluated by hematoxylin-eosin under a light microscope. Quantitative evaluation was performed via Movin and Bonar scoring. A computer-monitored tensile testing machine was utilised for biomechanical testing. Biomechanical characteristics of the tendon samples (elastic modulus, yield force, ultimate tensile force) were measured. Histopathological evaluation revealed a significantly higher Movin and Bonar scores in histopathological evaluation. Movin score in isotretinoin group was 4.1 ± 2.5 and it was 2.3 ± 1.0 in control group (p = 0.032). Bonar score in isotretinoin group was 2.9 ± 1.4 and it was 1.6 ± 0.7 in control group (p = 0.022). In line with histopathological evaluation, biomechanical measurements in isotretinoin gro...Continue Reading

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Citations

Sep 27, 2020·BMC Musculoskeletal Disorders·Nermin Karaosmanoğlu, Cevriye Mülkoğlu
Jul 22, 2021·Zeitschrift für Rheumatologie·Anja Hirschmüller, Oliver Morath

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Methods Mentioned

BETA
light microscopy

Software Mentioned

Movin

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