Isotretinoin-induced acne fulminans without systemic symptoms with concurrent exuberant granulation tissue

Pediatric Dermatology
Alvin W Li, Richard J Antaya

Abstract

Acne fulminans is a severe form of acne characterized by painful, inflammatory nodules that progress into ulcers and concurrent systemic symptoms. Treatment of acne with isotretinoin can precipitate a syndrome called isotretinoin-induced acne fulminans without systemic symptoms. An exuberant granulation tissue response, another known adverse event associated with isotretinoin, can occur concurrently, inhibiting wound repair and complicating treatment. We report a case of isotretinoin-induced acne fulminans without systemic symptoms with exuberant granulation tissue response that was treated successfully with topical clobetasol ointment.

References

Dec 1, 1984·The British Journal of Dermatology·D B RobertsonE C Gomez
Sep 6, 2000·Clinical and Experimental Dermatology·K F Thomson, W J Cunliffe
Jul 24, 2014·Anais Brasileiros De Dermatologia·Luciana Rosa GrandoTania Ferreira Cestari
Jun 18, 2017·Journal of the American Academy of Dermatology·Tanya GreywalSheila Fallon Friedlander

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Citations

May 19, 2020·Journal of the European Academy of Dermatology and Venereology : JEADV·Florence PoliBrigitte Dréno
Sep 20, 2018·Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Società Italiana Di Dermatologia E Sifilografia·Bruno GualtieriMarco Romanelli
Oct 22, 2020·Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Società Italiana Di Dermatologia E Sifilografia·Federica Dall'oglioGiuseppe Micali

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