Isotype Diversification of IgG Antibodies to HIV Gag Proteins as a Therapeutic Vaccination Strategy for HIV Infection

Vaccines
Martyn A FrenchSonia Fernandez

Abstract

The development of vaccines to treat and prevent human immunodeficiency virus (HIV) infection has been hampered by an incomplete understanding of "protective" immune responses against HIV. Natural control of HIV-1 infection is associated with T-cell responses against HIV-1 Gag proteins, particularly CD8⁺ T-cell responses restricted by "protective" HLA-B alleles, but other immune responses also contribute to immune control. These immune responses appear to include IgG antibodies to HIV-1 Gag proteins, interferon-a-dependant natural killer (NK) cell responses and plasmacytoid dendritic cell (pDC) responses. Here, it is proposed that isotype diversification of IgG antibodies against HIV-1 Gag proteins, to include IgG2, as well as IgG3 and IgG1 antibodies, will broaden the function of the antibody response and facilitate accessory cell responses against HIV-1 by NK cells and pDCs. We suggest that this should be investigated as a vaccination strategy for HIV-1 infection.

References

Jul 1, 1994·The Journal of Clinical Investigation·F BrièreJ Banchereau
Feb 1, 1995·Clinical and Experimental Immunology·D ChargelegueM W Steward
Sep 1, 1994·The Journal of Infectious Diseases·G VitharssonH Valdimarsson
Feb 1, 1996·Clinical and Experimental Immunology·H I ThomasP Morgan-Capner
Feb 1, 1997·Scandinavian Journal of Immunology·N KondoT Teramoto
Aug 28, 1999·Gastroenterology·N N ZeinD H Persing
Apr 25, 2000·AIDS Research and Human Retroviruses·M RauxC Blondeau
Oct 27, 2001·AIDS Research and Human Retroviruses·N Ngo-Giang-HuongUNKNOWN French Asymptomatic Long-Term Study Group
Mar 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Esther M YooSherie L Morrison
Sep 10, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ullvi BåveLars Rönnblom
Jan 31, 2004·Current Opinion in Allergy and Clinical Immunology·Simona Ferrari, Alessandro Plebani
Jan 26, 2005·The Journal of Clinical Investigation·Terry K MeansAndrew D Luster
Jan 5, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Edwin LeeansyahAnthony Jaworowski
Feb 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kaihong SuRobert P Kimberly
Mar 7, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jennifer P WangRobert W Finberg
Mar 27, 2007·Advances in Immunology·Qiang Pan-HammarströmLennart Hammarström
May 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Donald N ForthalTran Phan
Nov 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Donald N ForthalBenjamin Montoya
Dec 8, 2007·Nature Reviews. Immunology·Falk Nimmerjahn, Jeffrey V Ravetch
Jun 27, 2008·Intervirology·Kwang-Hyub Han, Ki Tae Yoon
Jul 22, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Danielle T AveryStuart G Tangye
Sep 19, 2008·Immunity·José A Villadangos, Louise Young

❮ Previous
Next ❯

Citations

Dec 18, 2018·International Journal of Rheumatic Diseases·Akira IizukaTakayuki Sumida
Apr 26, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·M Christian TjiamMartyn A French
Aug 28, 2020·Frontiers in Immunology·Madeleine F JenneweinGalit Alter
Jun 12, 2021·Acta Parasitologica·Maurício LlagunoVirmondes Rodrigues

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISAs
ELISA

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.