Isotype patterns of immunoglobulins: hallmarks for clinical status and tissue parasite density in Brazilian dogs naturally infected by Leishmania (Leishmania) chagasi

Veterinary Immunology and Immunopathology
Alexandre Barbosa ReisOlindo Assis Martins-Filho

Abstract

The role of anti-leishmanial immune response underlying the susceptibility/resistance during canine visceral leishmaniasis (CVL) has been recognized throughout ex vivo and in vitro investigations. Recently, we demonstrated that immunoglobulin levels (Igs), as well as the parasite load are relevant hallmarks of distinct clinical status of CVL. To further characterize and upgrade the background on this issue, herein, we have evaluated, in Leishmania (Leishmania) chagasi naturally infected dogs, the relationship between tissue parasitism (skin, bone marrow, spleen, liver and lymph node), the CVL clinical status (asymptomatic (AD), with no suggestive signs of the disease; oligosymptomatic (OD), with maximum three clinical signs-opaque bristles; localized alopecia and moderate loss of weight; symptomatic (SD), serologically positive with severe clinical signs of visceral leishmaniasis), and the humoral immunological profile of anti-Leishmania immunoglobulins (IgG, IgG1, IgG2, IgM, IgA and IgE). Our major statistically significant findings revealed distinct patterns of tissue parasite density within L. chagasi-infected dogs despite their clinical status, pointing out the spleen and skin as the most relevant sites of high parasitism d...Continue Reading

References

Jan 1, 1992·Memórias do Instituto Oswaldo Cruz·O GenaroW Mayrink
Dec 1, 1992·Veterinary Parasitology·C G NietoE Redondo
Sep 1, 1991·Parasite Immunology·P AbranchesC L Jaffe
Feb 15, 1985·Experientia·F Tischendorf
Jan 1, 1984·Veterinary Pathology·C M KeenanA J Johnson
Mar 1, 1995·The American Journal of Tropical Medicine and Hygiene·R B Tesh
Feb 1, 1995·Scandinavian Journal of Immunology·M M GicheruC Adhiambo
Mar 14, 1995·Proceedings of the National Academy of Sciences of the United States of America·S KarpatkinK B Hymes
Apr 1, 1993·Memórias do Instituto Oswaldo Cruz·G G OliveiraM Sadigursky
Dec 1, 1995·Annals of Tropical Medicine and Parasitology·M HommelG Milon
Feb 15, 2003·Veterinary Immunology and Immunopathology·R J QuinnellM J Day
Jul 15, 2004·Memórias do Instituto Oswaldo Cruz·Stella Maria Barrouin-MeloLain Pontes-de-Carvalho
Sep 8, 2004·Journal of Immunological Methods·Wagner Luiz TafuriWashington Luiz Tafuri
Oct 27, 2004·Advances in Parasitology·Jorge AlvarJavier Nieto
Jan 1, 2005·Veterinary Immunology and Immunopathology·Laura IniestaMontserrat Portús

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Citations

May 5, 2010·The American Journal of Tropical Medicine and Hygiene·Felicitat TodolíAlhelí Rodríguez-Cortés
May 24, 2011·Parasites & Vectors·Laia Solano-Gallego The LeishVet Group
May 22, 2010·Trends in Parasitology·Alexandre B ReisJavier Moreno
Mar 2, 2010·Veterinary Parasitology·Rafael Gonçalves Teixeira NetoAlexandre Barbosa Reis
Apr 7, 2009·Veterinary Parasitology·Trícia M F S OliveiraRosangela Z Machado
Jan 17, 2009·Veterinary Immunology and Immunopathology·Nádia das Dores MoreiraAlexandre Barbosa Reis
Nov 21, 2008·Veterinary Parasitology·Felicitat TodolíAlhelí Rodríguez-Cortés
Sep 16, 2008·Veterinary Parasitology·C Maia, L Campino
Jun 3, 2008·Trends in Parasitology·Gad BanethLluis Ferrer
Feb 26, 2008·Vaccine·Clarisa B Palatnik-de-Sousa
Oct 24, 2007·Research in Veterinary Science·Rodolfo Cordeiro GiunchettiRicardo Toshio Fujiwara
Aug 29, 2007·Veterinary Immunology and Immunopathology·Rodolfo Cordeiro GiunchettiAlexandre Barbosa Reis
Feb 27, 2007·Veterinary Immunology and Immunopathology·L CardosoM Rodrigues
Feb 25, 2010·Veterinary Dermatology·Manolis N Saridomichelakis
Nov 14, 2008·The Journal of Small Animal Practice·D SantoroP Ciaramella
Mar 10, 2010·European Journal of Immunology·Eszter DeakDiane McMahon-Pratt
Nov 14, 2006·Veterinary Immunology and Immunopathology·R S LageA B Reis
Apr 15, 2009·Research in Veterinary Science·M F MadeiraS R L Passos
Apr 21, 2016·Parasitology·Shazia HoseinLaia Solano-Gallego

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