PMID: 6980225Jan 1, 1982Paper

Isotypes of surface immunoglobulin on B lymphocytes from patients with immune deficiency

Journal of Clinical Immunology
J Schwaber, F S Rosen

Abstract

Peripheral blood lymphocytes from patients with antibody deficiency diseases (primarily agammaglobulinemia) were examined for the presence of B-lymphocyte subsets defined by surface immonoglobulin isotypes. The patients could be classified into one of four groups based upon the presence or absence of particular isotype-defined subsets. Patients with type I agammaglobulinemia lacked cells bearing surface IgG as well as IgD-Igm+-bearing cells. Type II agammaglobulinemia had unusually large numbers of IgG-bearing cells, representing as many as 50% of the peripheral blood B lymphocytes, while other B-cell subsets were present in normal numbers. Type III agammaglobulinemia had apparently normal numbers of all B-cell subsets. Hyper IgM immunodeficiency lacked cells bearing surface IgG, but did have all three iGd/IgM-bearing B-cell subsets. This classification of patients based upon B-cell subsets present in peripheral blood directly correlates with previous functional studies of B cells from these patients. We suggest that abnormal in vitro function of cells from these patients results from abnormal populations of B cells in peripheral blood, which result from the underlying disease.

References

Jan 1, 1977·Immunological Reviews·E S Vitetta, J W Uhr
Aug 1, 1978·The Journal of Clinical Investigation·J SchwaberF S Rosen
May 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·J SchwaberF S Rosen
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Dec 1, 1971·European Journal of Immunology·F P SiegalH G Kunkel

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Citations

Mar 1, 1997·Molecular Immunology·N KoenigJ Schwaber
Jul 1, 1985·The Journal of Investigative Dermatology·D W Wara

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