PMID: 8950589Nov 1, 1996Paper

Isovolemic hemodilution increases retinal tissue oxygen tension

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
K A NeelyJ Moss

Abstract

Therapeutic isovolemic hemodilution has been reported to improve blood flow and oxygen delivery. Few reliable measurements have been made, however, showing the effect of hemodilution on tissue oxygen tension. We measured retinal oxygen tension during experimental isovolemic hemodilution in normal cats. Polarographic oxygen microelectrodes were placed in the vitreous humor within 100-200 microns of the retinal surface. Tissue oxygen tension increased initially during isovolemic hemodilution to a maximum approximately 50% above baseline at approximately two thirds of the original hematocrit level. Hemodilution beyond this point to lower hematocrits caused a steady decline in tissue oxygen tension. Cardiac output measured in one cat undergoing isovolemic hemodilution increased as hematocrit was lowered, but the cardiac erythrocyte flux actually decreased steadily. The observed increase in tissue oxygen tension with hemodilution appears to be explained by a lesser reduction in capillary than in systemic hematocrit, coupled with an increased capillary blood flow. The increase in tissue oxygen tension we observed could in part explain the clinically beneficial effects of hemodilution.

Citations

May 19, 2007·Antioxidants & Redox Signaling·Pedro Cabrales, Marcos Intaglietta
Dec 17, 2009·British Journal of Anaesthesia·S Roth
Sep 29, 2001·Anesthesiology·S Roth, P Barach
Dec 14, 2004·Seminars in Ophthalmology·Maurizio Battaglia Parodi
Dec 9, 2004·Transfusion·Aryeh Shander, Tanuja S Rijhwani
Jan 18, 2017·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·N Feltgen, A Pielen
Feb 6, 2017·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·UNKNOWN Deutsche Ophthalmologische GesellschaftUNKNOWN Berufsverband der Augenärzte Deutschlands e. V.

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