Isovolemic hemodilution normalizes the prolonged passage of red cells and plasma through cerebral microvessels in the partially ischemic forebrain of rats

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
S Z LinY H Chiang

Abstract

The objective of this study was to determine whether hemodilution could normalize the mean transit times of red blood cells (Tr) and plasma (Tp) through cerebral microvessels in a partially ischemic brain. Wistar-Kyoto (WKY) rats, aged 30-40 weeks, were divided randomly into three groups. The first group was the nonocclusion, nonhemodilution (NN) normal control group. The second group was the occlusion, nonhemodilution (ON) group, in which animals were treated with bilateral carotid artery ligation. The third group was the occlusion-hemodilution (OH) group, in which animals were treated with bilateral common carotid artery ligation and, then, isovolemic hemodilution by replacing blood with the same volume of 3% modified fluid gelatin. Local cerebral blood flow (lCBF) and microvascular volumes of red blood cells (Vr) and plasma (Vp) in 14 brain structures were measured using 14C-iodoantipyrine, iron-55 labeled red blood cells, and 14C-inulin, respectively. The amount of oxygen delivered to local brain structures (OD), cerebral microvascular blood volume (Vb), mean transit time of blood (Tb), Tr, and Tp through cerebral microvessels were calculated from the data. Two hours after carotid artery ligation, lCBF decreased by approxim...Continue Reading

References

Mar 1, 1992·Stroke; a Journal of Cerebral Circulation·A HinoH Tenjin
Feb 1, 1992·Stroke; a Journal of Cerebral Circulation·H GoslingaP D Bezemer
Nov 1, 1990·Microvascular Research·S Z LinJ Fenstermacher
Apr 1, 1990·The American Journal of Physiology·P A LucchesiT W Honeyman
Nov 1, 1990·Journal of Applied Physiology·S Z LinJ Fenstermacher
Jul 1, 1989·Stroke; a Journal of Cerebral Circulation·S VorstrupG Boysen
Jan 1, 1973·Acta Physiologica Scandinavica·B Eklöf, B K Siesjö
Sep 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K F WaschkeW Kuschinsky
Nov 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S B CoxC M Rovainen
May 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·D BereczkiJ Fenstermacher
May 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·L WeiJ Fenstermacher

❮ Previous
Next ❯

Citations

May 12, 2004·Critical Care Clinics·Paul C HébertLing Qun Hu
Mar 4, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A G HudetzJ P Kampine
Jan 11, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Dominique ErniAndrej Banic

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.