Isradipine increases vascular prostaglandin I2-formation while the thromboxane B2-synthesis is diminished

Thrombosis Research
H KritzH Sinzinger

Abstract

PGI2- and TXA2-synthesis from vascular tissue samples derived from cultured (endothelial and smooth muscle) cells, rabbit aorta and human bypass surgery were determined using specific radioimmunoassays for the stable derivatives (6-oxo-PGF1a and TXB2, respectively) of these compounds. Cultured cells were incubated in presence of isradipine, rabbits were pretreated for 4 weeks receiving 0.3 mg isradipine/kg*day, while patients were on isradipine (5-10 mg total dose/day, per os twice daily) since 6-19 weeks. In presence of isradipine, cultured cells produced significantly (p < 0.01) more 6-oxo-PGF1a and significantly less TXB2 (p < 0.05). 6-oxo-PGF1a-formation in rabbit aorta was significantly (p < 0.01) higher in isradipine treated normocholesterolemic animals while no significant changes were seen in isradipine treated hypercholesterolemic animals. TXB2 was significantly (p < 0.01) depressed in the abdominal and the thoracic aortic segment of isradipine treated hypercholesterolemic animals and was not significantly influenced in isradipine treated normocholesterolemic animals. Similarly, PGI2-synthesis in human arterial specimen was significantly (p < 0.01) enhanced as compared to the untreated controls. These findings indicate...Continue Reading

References

Sep 1, 1979·Lancet·H SinzingerK Silberbauer
Jan 1, 1992·European Journal of Clinical Pharmacology·H SinzingerJ O'Grady
Nov 1, 1989·Atherosclerosis·C L JacksonD E Bowyer
May 1, 1995·Hypertension·S E KjeldsenS Julius
Mar 1, 1994·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·P FitschaH Sinzinger
Mar 1, 1993·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·P A van Zwieten, M Pfaffendorf

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