PMID: 9184708Jun 1, 1997Paper

Isradipine therapy in hypertensive pediatric patients

The Annals of Pharmacotherapy
C E JohnsonM H Song

Abstract

To evaluate the dosage and effectiveness of isradipine to control acute or chronic hypertension in pediatric patients. Retrospective medical record review. University teaching hospital. Hospitalized pediatric patients aged 1 day to 16 years with hypertension treated with isradipine between January 1994 and March 1996. Patient age, gender, weight, disease states, current medications, isradipine dosage and formulation, pre- and postsystolic, and pre- and postdiastolic blood pressure measurements with each dose of isradipine. Fifty-three patients with a mean age of 5.8 +/- 4.0 years were evaluated. A mean change in the blood pressure measurements taken before the first dose of isradipine compared with the values recorded after the last dose or at discharge for all patients was -11.8% +/- 12.5% and -17.4% +/- 19.6%, respectively, for systolic and diastolic pressure. The mean dosage of isradipine in 46 patients who received regularly scheduled doses was 0.38 +/- 0.22 mg/kg/d. Patients who demonstrated a response received a mean dosage of 0.40 +/- 0.20 mg/kg/d. The total daily dosage was administered in one dose for 1 patient, two doses for 15 patients, three doses for 27 patients, and four doses for 3 patients. Isradipine was an eff...Continue Reading

References

Mar 1, 1990·Pediatric Emergency Care·E ShaharZ Barzilay
Jul 1, 1994·American Journal of Hypertension·F Rocha-GonçalvesG Mariano-Pego
Feb 1, 1993·Pediatric Clinics of North America·A R Sinaiko

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Citations

Mar 22, 2005·Paediatric Drugs·Renee F RobinsonJohn D Mahan
Oct 21, 2000·American Journal of Hypertension·J T FlynnT E Bunchman
Nov 9, 2010·The Journal of Clinical Hypertension·Yosuke MiyashitaJoseph T Flynn
Nov 7, 2007·Journal of Hypertension·Giacomo D SimonettiMario G Bianchetti
Jul 21, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jayanthi Chandar, Gastón Zilleruelo
Sep 6, 2011·Paediatric Drugs·Christopher A Thomas
Mar 11, 2000·Pharmacotherapy·M E Temple, M C Nahata
Jul 11, 2001·The Journal of Pediatrics·J T FlynnT E Bunchman
Aug 19, 2007·The Journal of Emergency Medicine·Claudia Ranniger, Colleen Roche

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