Issues and strategies in the genetic analysis of alcoholism and related addictive behaviors

Alcohol
N J Schork, C M Schork

Abstract

Research into the genetics of alcoholism susceptibility and related behaviors has become highly contentious for a number of reasons: at issue is the identification of factors that may ultimately determine human behaviors, the limitations of the technologies being used to conduct relevant studies have not been assessed exhaustively, and independent studies have produced widely different results. Addressing these and other questions of relevance in the dissection of the genetic basis of alcoholism susceptibility will be nothing if not difficult. In this article, we consider issues related to one not-so-minor research angle being used more and more in investigations of alcoholism and related disorders: the identification of susceptibility loci through the use of anonymous (or seemingly anonymous) DNA markers. We also consider issues that might promote (or resist) the reconcilability of independent study results, and describe some basic strategies that might help make study results more compelling in light of the complexity of alcoholism and related behaviors.

References

Aug 1, 1992·Alcoholism, Clinical and Experimental Research·B L CookM Freimer
May 1, 1992·Journal of Affective Disorders·P MitchellJ Shine
Jul 1, 1991·Alcohol·S C WhippleE P Noble
Jul 1, 1991·Journal of Studies on Alcohol·S C Whipple, E P Noble
Nov 1, 1990·Archives of General Psychiatry·J GelernterK K Kidd
Jul 1, 1991·Archives of General Psychiatry·H W MoisesJ L Kennedy
Jul 1, 1991·Archives of General Psychiatry·A ParsianC R Cloninger
Oct 20, 1995·Science·V E VelculescuK W Kinzler
Jun 1, 1995·Alcoholism, Clinical and Experimental Research·S Y HillJ Locke
Jan 1, 1995·European Archives of Psychiatry and Clinical Neuroscience·C R CloningerD M Svrakic
Nov 15, 1993·Biochemical and Biophysical Research Communications·M ItokawaM Toru
Dec 1, 1993·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·J R KelsoeJ A Egeland
Apr 23, 1994·Lancet·S ShaikhR Kerwin
Jul 29, 1994·Biochemical and Biophysical Research Communications·M HattoriH Kazamatsuri
Jan 1, 1994·European Archives of Psychiatry and Clinical Neuroscience·T GeijerL Terenius
Jun 1, 1994·Current Opinion in Genetics & Development·M S Boguski
Nov 15, 1994·Biochemical and Biophysical Research Communications·S HiguchiM Hayashida
Apr 1, 1994·Genetics·Z B Zeng
Sep 30, 1994·Science·E S Lander, N J Schork
Apr 1, 1993·Journal of Psychiatric Research·S AmadéoY Leclaire
Jan 1, 1994·Journal of Studies on Alcohol·M A Schuckit
Apr 1, 1994·The International Journal of Eating Disorders·E P NobleD K Grandy
Oct 15, 1993·Biochemical and Biophysical Research Communications·S R GeorgeB F O'Dowd
Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·Z B Zeng
Oct 1, 1993·Drug and Alcohol Dependence·E P NobleM D Anglin
Mar 1, 1993·Comprehensive Psychiatry·C A DeJongE G van der Wielen
Aug 15, 1993·Biological Psychiatry·C L Barr, K K Kidd

❮ Previous
Next ❯

Citations

Jun 28, 2003·Criminal Behaviour and Mental Health : CBMH·David BestE Jane Marshall
May 10, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Ru-Band LuJean Chen Shih
Apr 20, 2002·Addiction·Melissa S Gerald, J Dee Higley
Jan 12, 2000·Alcoholism, Clinical and Experimental Research·S F StoltenbergR A Zucker
Mar 15, 2014·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Abdulla A-B Badawy
Dec 31, 2005·Alcoholism, Clinical and Experimental Research·Ru-Band LuYuan-Hwa Chou
Sep 30, 2006·Progress in Neuro-psychopharmacology & Biological Psychiatry·Tso-Jen WangRu-Band Lu
Oct 23, 2016·Journal of Hepatology·Felix StickelMarsha Y Morgan
Sep 5, 2002·The American Journal of Drug and Alcohol Abuse·Glenn D Walters

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.