Issues for the management of people with diabetes and COVID-19 in ICU

Cardiovascular Diabetology
Antonio Ceriello“Diabetes and Cardiovascular Disease (D&CVD)” Study Group of the European Association for the Study of Diabetes (EASD)

Abstract

In the pandemic "Corona Virus Disease 2019" (COVID-19) people with diabetes have a high risk to require ICU admission. The management of diabetes in Intensive Care Unit is always challenging, however, when diabetes is present in COVID-19 the situation seems even more complicated. An optimal glycemic control, avoiding acute hyperglycemia, hypoglycemia and glycemic variability may significantly improve the outcome. In this case, intravenous insulin infusion with continuous glucose monitoring should be the choice. No evidence suggests stopping angiotensin-converting-enzyme inhibitors, angiotensin-renin-blockers or statins, even it has been suggested that they may increase the expression of Angiotensin-Converting-Enzyme-2 (ACE2) receptor, which is used by "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to penetrate into the cells. A real issue is the usefulness of several biomarkers, which have been suggested to be measured during the COVID-19. N-Terminal-pro-Brain Natriuretic-Peptide, D-dimer and hs-Troponin are often increased in diabetes. Their meaning in the case of diabetes and COVID-19 should be therefore very carefully evaluated. Even though we understand that in such a critical situation some of these requests...Continue Reading

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Citations

Dec 7, 2020·Cardiovascular Diabetology·Abdullah M AlguwaihesAnwar A Jammah
Jan 11, 2021·Clinical Obesity·Andrej BelančićMarija Troskot Dijan
Oct 5, 2020·Diabetes Research and Clinical Practice·Antonio Ceriello
Feb 19, 2021·Journal of Medical Internet Research·Alaa Abd-AlrazaqZubair Shah
Mar 16, 2021·Current Clinical Microbiology Reports·Christina L BugertMichelle S Parvatiyar
Apr 2, 2021·Cardiovascular Diabetology·Oliver SchnellEberhard Standl
Apr 27, 2021·Journal of Diabetes and Its Complications·Antonio Ceriello, Francesco Prattichizzo
May 9, 2021·Cardiovascular Diabetology·Nunzia D'OnofrioRaffaele Marfella
Jun 1, 2021·Clinical Nutrition Open Science·Debas Yaregal Melesse, Wubie Birlie Chekol
May 25, 2021·Obesity Medicine·Amir EmamiAliAkbar Rezaei
Jul 22, 2021·Cardiovascular Diabetology·Hélène BihanEmmanuel Cosson
Aug 2, 2021·Metabolism: Clinical and Experimental·Manfredi RizzoChristos S Mantzoros
Jul 4, 2021·The FEBS Journal·Zhen Wei Marcus TongKirsty R Short
Aug 24, 2021·Expert Opinion on Drug Safety·Yajnavalka BanerjeeManfredi Rizzo

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