Issues of Adipokine Regulation in Idiopathic Pulmonary Arterial Hypertension and Systemic Osteopenia

Kardiologiia
E A KochetkovaT A Brodskaya

Abstract

to determine the role of adipokines and vascular remodeling in formation of osteoporosis in idiopathic pulmonary arterial hypertension (IPAH). Functional and hemodynamic parameters, bone mineral density (BMD) T-score in lumbar spine (LS) and femoral neck (FN), blood serum levels of leptin, adiponectin, visfatin and endothelin-1 were measured in 27 patients with severe IPAH and 30 healthy volunteers. Half of IPAH patients had osteoporosis. Serum levels of leptin, adiponectin, visfatin and endothelin-1 in IPAH group were higher than in healthy volunteers. BMD T-score was directly related to results of 6‑minute walk test and inversely related to pulmonary vascular resistance (PVR). Circulating adiponectin and visfatin concentrations correlated with PVR; endothelin-1 concentration was directly related to pulmonary arterial systolic pressure, cardiac index and PVR. Relations between BMD T-score and circulating adiponectin, visfatin, and endothelin-1 were inverse. Positive correlations existed between serum adiponectin, visfatin and endothelin-1 levels. Results of our study confirm the important role of adipokine and endotheline dysregulation in development of hemodynamic disorders in severe IPAH and evidence for their possible invol...Continue Reading

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