PMID: 19930974Nov 26, 2009Paper

Issues of imatinib and pregnancy outcome

Journal of the National Comprehensive Cancer Network : JNCCN
Jane Apperley

Abstract

The introduction of tyrosine kinase inhibitors into clinical practice now offers most patients with chronic myelogenous leukemia lengthy remissions and the possibility of normal life expectancies. These improved survivals have resulted in the need to address issues relating to quality of life, including fertility and procreation. Treatment may require lifelong daily therapy with drugs that might inhibit proteins essential to gonadal function, implantation, and embryogenesis. Animal data suggest that imatinib at standard dosages is unlikely to impair fertility in either adult male or female animals. However, human data remain limited, particularly in children and adolescents. Children born to men who are actively taking imatinib at conception seem healthy, and current advice is not to discontinue treatment. In contrast, data are less encouraging for children born to women exposed to imatinib during pregnancy. Although numbers are small, a disturbing cluster of rare congenital malformations has prevented imatinib from being recommended safely, particularly during the period of organogenesis. Alternative strategies for managing pregnancy in chronic myelogenous leukemia include one or both of regular leukapheresis and interferon-al...Continue Reading

Citations

Sep 29, 2011·The Oncologist·Alberuni M ZamahMitchell P Rosen
Jun 11, 2016·Japanese Journal of Clinical Oncology·Shingo MiyamotoKazumichi Andoh
Mar 17, 2012·Anti-cancer Drugs·Paul BerveillerVassilis Tsatsaris
May 26, 2016·Investigational New Drugs·Cynthia M NijenhuisJan H M Schellens
Jan 19, 2019·Molecular and Clinical Oncology·Merav BarzilaiOdelia Amit
May 19, 2020·Japanese Journal of Clinical Oncology·Masahiro Ashizawa, Yoshinobu Kanda
Mar 11, 2011·Blood·Jean-Jacques KiladjianRonald Hoffman
Mar 2, 2013·The Journal of Clinical Endocrinology and Metabolism·Maya B Lodish
Jul 1, 2014·British Journal of Haematology·Josu de la FuenteUNKNOWN International BFM Group (iBFM) Study Group Chronic Myeloid Leukaemia Committee
Aug 9, 2020·Journal of Assisted Reproduction and Genetics·Silvina J RiosFrancisca Ferrer-Marín
Dec 12, 2017·Obstetric Medicine·Mathieu PuyadeOlivier Pourrat
Aug 1, 2020·British Journal of Haematology·Graeme SmithUNKNOWN British Society for Haematology

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