ISTA13--international interlaboratory comparative evaluation of microbial assay for risk assessment (MARA)

Environmental Toxicology
K Wadhia

Abstract

The microbial assay for risk assessment (MARA) is an innovative system based on an array of 11 different microbial species freeze-dried in a 96-well micro-titer plate. Developed for testing the toxicity of chemicals, mixtures, and environmental samples, the assay employs species of a taxonomically diverse range. In addition to 10 prokaryotic species, a eukaryote (yeast) is included in the range. The MARA's innate scope of a multi-dimensional test allows determination of toxicity based on a unique assay fingerprint or index, numerically expressed as the mean microbial toxic concentration (MTC). The most significant potential of the test is in the additional inference that can be conveyed to the toxicity evaluation because of the presence of each of the constituent species. The performance of MARA was evaluated to ascertain its capability and potential scope in an intralaboratory trial. Sensitivity to toxicants and different environmental samples was assessed. Evaluation included comparison with other tests; namely Microtox, invertebrate (Daphnia magna and Thamnocephalus platyurus) microbiotests, and respiration- and nitrification-inhibition tests. MARA's performance was further assessed with the implementation of an internationa...Continue Reading

References

Jan 29, 2000·Ecotoxicology and Environmental Safety·A E GirlingG Persoone
Jun 22, 2000·Risk Analysis : an Official Publication of the Society for Risk Analysis·G W Suter
Oct 7, 2004·Ecotoxicology·Elizabeth A Power, Ruth S Boumphrey
Jul 15, 2006·Environmental Toxicology·Livia MarianiErika Magaletti

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Citations

Jan 25, 2017·Environmental Science and Pollution Research International·Ariel MarchlewiczDanuta Wojcieszyńska

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