iStent Trabecular Microbypass Stent Implantation with Phacoemulsification in Patients with Open-Angle Glaucoma: 6-Year Outcomes

Clinical Ophthalmology
Tanner FergusonJohn P Berdahl

Abstract

To investigate the long-term safety and efficacy of an iStent trabecular microbypass stent in combination with cataract surgery in eyes with primary open-angle glaucoma (POAG). Private practice; Sioux Falls, South Dakota. Retrospective, consecutive case series. This case series included eyes implanted with a single trabecular microbypass stent in combination with phacoemulsification in patients with mild to severe POAG. Data were collected preoperatively and at day 1, week 1, month 1, and up to 6 years postoperatively. Primary outcome measures included mean intraocular pressure (IOP) and number of glaucoma medications. Safety was noted by assessing the incidence of IOP spikes and need for additional surgery. The study comprised 411 eyes. Mean IOP was reduced to 14.9±4.2 mmHg compared to 18.8±5.6 mmHg at baseline at 6 years postoperative. The mean number of medications was reduced to 1.2±1.0 from 1.4±1.1 at baseline. In eyes with severe stage of disease, there was a mean IOP reduction >6 mmHg at 6 years postoperative. Eyes with baseline IOP ≥18 mmHg achieved a more robust reduction in IOP. Fifteen eyes underwent a secondary glaucoma procedure. There were no intra- or postoperative complications. Trabecular microbypass stent impl...Continue Reading

References

Oct 9, 2002·Archives of Ophthalmology·Anders HeijlUNKNOWN Early Manifest Glaucoma Trial Group
Jun 9, 2005·American Journal of Ophthalmology·Henry D JampelUNKNOWN Collaborative Initial Glaucoma Treatment Study Group
Aug 10, 2007·American Journal of Ophthalmology·Alan L RobinTania S Marcic
May 13, 2008·Journal of Cataract and Refractive Surgery·Brooks J PoleyThomas W Samuelson
Feb 22, 2011·Journal of Glaucoma·Raghav GuptaTanuj Dada
Jan 18, 2012·Current Opinion in Ophthalmology·Hady Saheb, Iqbal Ike K Ahmed
May 23, 2012·Ophthalmology·Steven L MansbergerUNKNOWN Ocular Hypertension Treatment Study Group
Sep 18, 2012·Journal of Cataract and Refractive Surgery·Graham W BelovayIqbal Ike K Ahmed
Feb 27, 2015·Journal of Glaucoma·Heleen DelbekeThierry Zeyen
Nov 17, 2015·Current Opinion in Ophthalmology·Manjool ShahIqbal Ike K Ahmed
Nov 20, 2015·Ophthalmology·Bruce E PrumRuth D Williams
Feb 13, 2016·Clinical Ophthalmology·Grace M Richter, Anne L Coleman
Dec 19, 2018·Current Opinion in Ophthalmology·Jenny Chen, Steven J Gedde

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