ISU201 enhances the resolution of airway inflammation in a mouse model of an acute exacerbation of asthma

Mediators of Inflammation
Yuka HiroshimaCristan Herbert

Abstract

Glucocorticoids are commonly used for treating asthma and its exacerbations but have well-recognised adverse effects and are not always effective. Few alternative treatments exist. Using a murine model of an acute exacerbation of asthma, we assessed the ability of ISU201, a novel protein drug, to suppress the inflammatory response when administered after induction of an exacerbation. Sensitised mice were chronically challenged with a low mass concentration of aerosolised ovalbumin, and then received a single moderate-level challenge to simulate an allergen-induced exacerbation. ISU201 was administered to mice 2 and 8 hours later, while pulmonary inflammation and expression of mRNA for chemokines and proinflammatory cytokines were assessed after 4, 12, and 24 hours. Relative to vehicle-treated controls, ISU201 suppressed accumulation of pulmonary neutrophils and eosinophils, while accelerating the decline in CXCL1, TNF-α, and IL-6 in lavage fluid and lung tissue. ISU201 significantly reduced peak expression of mRNA for the chemokines Cxcl9 and Cxcl10, the adhesion molecules Icam1 and Vcam1, and the proinflammatory cytokines Il1b, Il12p40, and Csf1. The ability of ISU201 to promote resolution of inflammation suggests that it may ...Continue Reading

References

Jul 29, 2000·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·B J Lipworth, C M Jackson
Oct 21, 2000·European Journal of Pharmacology·X ZhangH Kankaanranta
May 19, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S de Magalhães SimõesM Dolhnikoff
Jun 15, 2006·Nature Reviews. Drug Discovery·Luke A J O'Neill
Jun 24, 2006·American Journal of Respiratory Cell and Molecular Biology·Jessica S SiegleRakesh K Kumar
Feb 3, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Charles N SerhanJohn L Wallace
Mar 1, 2008·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C HerbertR K Kumar
Dec 19, 2008·Disease Models & Mechanisms·Anthony T Nials, Sorif Uddin
Jan 13, 2009·American Journal of Respiratory and Critical Care Medicine·Sally E WenzelUNKNOWN T03 Asthma Investigators
May 21, 2009·BMC Pulmonary Medicine·Katayoun BahadoriJ Mark FitzGerald
Jun 19, 2009·American Journal of Respiratory and Critical Care Medicine·Helen K ReddelUNKNOWN American Thoracic Society/European Respiratory Society Task Force on Asthma Control and Exacerbations
Jan 9, 2010·American Journal of Respiratory and Critical Care Medicine·Jonathan CorrenShao-Lee Lin
Apr 24, 2010·Current Drug Targets·Wan WangMing Yang
Jun 18, 2010·Trends in Pharmacological Sciences·Peter J Barnes
Nov 26, 2010·Cellular Immunology·Hyouna YooMyung Kim
Mar 17, 2011·Current Pharmaceutical Design·A DurhamO Tliba
Aug 20, 2011·American Journal of Respiratory and Critical Care Medicine·Mario CastroUNKNOWN Res-5-0010 Study Group
Feb 2, 2012·Expert Opinion on Emerging Drugs·Garry M Walsh
Apr 16, 2013·Pharmacology & Therapeutics·Ana L AlessandriMauro M Teixeira
Dec 29, 2013·The Journal of Allergy and Clinical Immunology·Richard BeasleyHelen K Reddel

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Citations

Oct 16, 2012·Prostaglandins & Other Lipid Mediators·Anna Maria Giudetti, Raffaele Cagnazzo
Feb 29, 2016·Respirology : Official Journal of the Asian Pacific Society of Respirology·Rakesh K KumarPaul S Foster
Dec 19, 2017·The Journal of International Medical Research·Ping HuangGuiyuan Lv

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Methods Mentioned

BETA
protein assay
ELISA
PCR
lavage
acetylation

Software Mentioned

GraphPad Prism
GraphPad

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