It Takes "Guts" to Cause Joint Inflammation: Role of Innate-Like T Cells

Frontiers in Immunology
Céline MortierDirk Elewaut

Abstract

Innate-like T cells such as invariant natural killer T (iNKT) cells and mucosal-associated T (MAIT) cells, characterized by a semi-invariant T cell receptor and restriction toward MHC-like molecules (CD1 and MR1 respectively), are a unique unconventional immune subset acting at the interface of innate and adaptive immunity. Highly represented at barrier sites and capable of rapidly producing substantial amounts of cytokines, they serve a pivotal role as first-line responders against microbial infections. In contrast, it was demonstrated that innate-like T cells can be skewed toward a predominant pro-inflammatory state and are consequently involved in a number of autoimmune and inflammatory diseases like inflammatory bowel diseases and rheumatic disorders, such as spondyloarthritis (SpA) and rheumatoid arthritis. Interestingly, there is link between gut and joint disease as they often co-incide and share certain aspects of the pathogenesis such as established genetic risk factors, a critical role for pro-inflammatory cytokines, such as TNF-α, IL-23, and IL-17 and therapeutic susceptibility. In this regard dysregulated IL-23/IL-17 responses appear to be crucial in both debilitating pathologies and innate-like T cells likely act a...Continue Reading

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Citations

Jan 23, 2020·Journal of Clinical Laboratory Analysis·Sarra MelayahIbtissem Ghedira
Feb 15, 2020·Cancers·Zuzanna LukasikKoen Venken
Jul 7, 2019·Annals of the Rheumatic Diseases·Dennis G McGonagleRobert Moots
Jun 6, 2019·Arthritis Research & Therapy·Daniel E Furst, James S Louie
Jun 30, 2019·PloS One·Slimane AllaliMaria Leite-de-Moraes
Feb 25, 2021·Seminars in Immunopathology·Zoya QaiyumRobert D Inman
Jun 12, 2021·Nature Reviews. Rheumatology·Daniele MauroFrancesco Ciccia

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