'It takes two to tango': Bridging the gap between country need and vaccine product innovation

PloS One
Rachel ArcherRaymond C W Hutubessy

Abstract

Despite a growing global commitment to universal health coverage, considerable vaccine coverage and uptake gaps persist in resource-constrained settings. One way of addressing the gaps is by ensuring product innovation is relevant and responsive to the needs of these contexts. Total Systems Effectiveness (TSE) framework has been developed to characterize preferred vaccine attributes from the perspective of country decision-makers to inform research and development (R&D) of products. A proof of concept pilot study took place in Thailand in 2018 to examine the feasibility and usefulness of the TSE approach using a rotavirus hypothetical test-case. The excel-based model used multiple-criteria decision analysis (MCDA) to compare and evaluate five hypothetical rotavirus vaccine products. The model was populated with local data and products were ranked against decision criteria identified by Thai stakeholders. A one-way sensitivity analysis was performed to identify criteria that influenced vaccine ranking. Self-assessment forms were distributed to R&D stakeholders on the usability of the approach and were subsequently analysed. The model identified significant parameters that impacted on MCDA rankings. Self-assessment forms revealed...Continue Reading

References

Jun 12, 2010·Bulletin of the World Health Organization·David B Evans, Carissa Etienne
Jul 15, 2015·BMC Health Services Research·Philip WahlsterUNKNOWN National Leading-Edge Cluster Medical Technologies ‘Medical Valley EMN’
Oct 17, 2015·Current Medical Research and Opinion·Olga Popova, Patricia Ibarra de Palacios
Mar 30, 2016·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Kevin MarshUNKNOWN ISPOR Task Force
May 26, 2017·Vaccine·Benjamin HicklerUNKNOWN Strategic Advisory Group of Experts on immunization (SAGE) Working Group on Decade of Vaccines
Jun 26, 2017·Vaccine·Stanley PlotkinShannon Larsen
Sep 2, 2017·European Journal of Immunology·Dylan SheerinAndrew J Pollard
Aug 10, 2018·Expert Review of Pharmacoeconomics & Outcomes Research·András InotaiZoltán Kaló
Nov 2, 2018·BMC Medical Informatics and Decision Making·Talita D C FrazãoRicardo P Souza
Nov 21, 2018·Cost Effectiveness and Resource Allocation : C/E·Kevin MarshKalipso Chalkidou
Feb 18, 2020·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Nivedita KamathArpana Iyengar

❮ Previous
Next ❯

Software Mentioned

UNIVAC
Vaccine - Technology Impact Assessment ( V - TIA ) tool
MCDA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.