PMID: 8945639Nov 1, 1996Paper

ITA, a vertebrate homologue of IAP that is expressed in T lymphocytes

DNA and Cell Biology
M R DigbyJ Lowenthal

Abstract

Apoptosis plays a crucial role in both the development and the control of the immune system. During T lymphocyte development, thymocytes undergo apoptosis as part of the process of elimination of self-reactive clones. Mature T cells also undergo apoptosis following antigen-stimulated proliferation as part of a mechanism that controls the immune response. Apoptosis also provides a defense mechanism against viruses whereby the rapid death of virus-infected cells reduces virus spread. Viruses, on the other hand, often express proteins that inhibit apoptosis of their host cells, thereby enhancing their infectivity. We have isolated a novel gene, ita (inhibitor of T cell apoptosis), which is a vertebrate homologue of the viral apoptosis inhibitor IAP. Expression of ita appears to be restricted to cells of the T lymphocyte lineage, and high levels of ita mRNA are induced within 4-8 hr of T cell activation. Immunohistologic studies show that medullary and cortical thymocytes express detectable levels of ITA. ITA is a 69 kDa protein that contains a C-terminal ring-finger motif that is found in several oncogenic proteins and N-terminal repeat elements that have only been reported in other apoptosis inhibitors. These findings suggest tha...Continue Reading

References

Mar 1, 1991·Journal of Virology·K A SchatD Char
Feb 15, 1990·Nature·H R MacDonald, R K Lees
Dec 1, 1985·Medical Hypotheses·W M Clouston, J F Kerr
Jan 1, 1995·Annual Review of Immunology·S Cory
Jan 1, 1994·Annual Review of Immunology·K Pfeffer, T W Mak
Oct 21, 1994·Cell·Z N Oltvai, S J Korsmeyer
Dec 1, 1993·Journal of Neurochemistry·S RabizadehD E Bredesen
Jul 1, 1993·Immunology Today·D KabelitzK Pechhold
Apr 1, 1993·Journal of Virology·N E CrookL K Miller
Nov 1, 1995·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·J W LowenthalJ J York

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Citations

Jan 25, 2002·Biotechnology and Bioengineering·Tina M SauerwaldGeorge A Oyler
May 6, 2003·Biochemical and Biophysical Research Communications·David L Vaux, John Silke
Feb 28, 2002·The European Journal of Neuroscience·Natale BelluardoDan Lindholm
Apr 14, 2000·Brain Pathology·G S RobertsonJ B Schulz
Jul 24, 2001·Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders : Official Publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases·M BeckM Sendtner
Dec 9, 2008·Journal of Medical Entomology·Julia W PridgeonKenneth J Linthicum
Sep 14, 2004·Thérapie·Christiane Charriaut-Marlangue
Aug 24, 2002·Endocrinology·A L JohnsonJ T Bridgham
Jan 7, 1998·Molecular and Cellular Biology·C S DuckettR C Armstrong

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