Nov 7, 2019

Italian consensus recommendations for a biomarker-based aetiological diagnosis in mild cognitive impairment patients

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
Marina BoccardiGiovanni B Frisoni

Abstract

Biomarkers support the aetiological diagnosis of neurocognitive disorders in vivo. Incomplete evidence is available to drive clinical decisions; available diagnostic algorithms are generic and not very helpful in clinical practice. The aim was to develop a biomarker-based diagnostic algorithm for mild cognitive impairment patients, leveraging on knowledge from recognized national experts. With a Delphi procedure, experienced clinicians making variable use of biomarkers in clinical practice and representing five Italian scientific societies (neurology - Società Italiana di Neurologia per le Demenze; neuroradiology - Associazione Italiana di Neuroradiologia; biochemistry - Società Italiana di Biochimica Clinica; psychogeriatrics - Associazione Italiana di Psicogeriatria; nuclear medicine - Associazione Italiana di Medicina Nucleare) defined the theoretical framework, relevant literature, the diagnostic issues to be addressed and the diagnostic algorithm. An N-1 majority defined consensus achievement. The panellists chose the 2011 National Institute on Aging and Alzheimer's Association diagnostic criteria as the reference theoretical framework and defined the algorithm in seven Delphi rounds. The algorithm includes baseline clinic...Continue Reading

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Mentioned in this Paper

Biological Markers
In Vivo
Delphi Technique
Tomography, Emission-Computed, Single-Photon
Magnetic Resonance Imaging
Granulocyte Colony-Stimulating Factor
National Area
Procedure on Heart
Cerebrospinal Fluid
Alzheimer's Disease

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