Italian Society of Arterial Hypertension (SIIA) Position Paper on the Role of Renal Denervation in the Management of the Difficult-to-Treat Hypertensive Patient

High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension
Rosa Maria BrunoClaudio Ferri

Abstract

Renal denervation is a device-based procedure for hypertension for which safety and efficacy has been demonstrated. At present, its clinical use is still matter of debate, despite the most recent clinical trials have shown promising results with new-generation devices in various hypertensive populations. This position paper was deemed necessary by the Italian Society of Arterial Hypertension, in order to provide indications about the applications of renal denervation in the clinical setting. A state-of-the art review of the literature, focusing on safety and efficacy data, is provided. Furthermore, based on current evidence and expert consensus, clinical profiles of possible candidates for renal denervation are proposed. The selection process should take into account not only blood pressure values, global cardiovascular risk profile, but also drug adherence and tolerability and patient preferences. This position paper also defines minimum requirements for renal denervation selection centers and a flowchart for the difficult-to-treat hypertensive patient. Further studies are needed to support these preliminary indications, which are based on expert-consensus only.

References

Feb 1, 1983·American Journal of Public Health·D E MoriskyC R Smith
May 6, 2008·Lancet·Carlene M M LawesUNKNOWN International Society of Hypertension
Dec 16, 2010·Journal of Hypertension·Giovanni CorraoGiuseppe Mancia
Jul 4, 2012·The American Journal of Medicine·Sayed H NaderiDavid S Wald
Jul 11, 2012·BMJ : British Medical Journal·Iain J MarshallChristopher McKevitt
Feb 23, 2013·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Massimo VolpeUNKNOWN Italian Society of Hypertension
Mar 29, 2013·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Massimo VolpeUNKNOWN Italian Society of Hypertension
Sep 5, 2013·JAMA : the Journal of the American Medical Association·Clara K ChowUNKNOWN PURE (Prospective Urban Rural Epidemiology) Study investigators
Oct 18, 2013·Journal of Hypertension·Mustafa EzzahtiAnton H van den Meiracker
Dec 10, 2013·Journal of the American College of Cardiology·Stephanie BrinkerWanpen Vongpatanasin
Dec 25, 2013·European Heart Journal·Stefano F RimoldiFranz H Messerli
Apr 1, 2014·The New England Journal of Medicine·Deepak L BhattUNKNOWN SYMPLICITY HTN-3 Investigators
Nov 18, 2014·European Heart Journal·David E KandzariGeorge L Bakris
Oct 16, 2015·The Journal of Clinical Hypertension·Giuliano TocciUNKNOWN Working Group of the Italian Society of Hypertension (SIIA) and SIIA Foundation
Apr 14, 2016·British Journal of Clinical Pharmacology·Emily A F HolmesDyfrig A Hughes
Feb 25, 2017·Journal of the American College of Cardiology·Reetu R SinghKate M Denton
Mar 9, 2017·European Radiology·Margreet F SandersUNKNOWN European Network COordinating research on Renal Denervation (ENCOReD) Consortium
Aug 24, 2017·Circulation. Cardiovascular Quality and Outcomes·Antoinette SchoenthalerGbenga Ogedegbe
Oct 24, 2017·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Margreet F SandersPeter J Blankestijn
Mar 14, 2018·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Alain LekoubouBruce Ovbiagele
May 11, 2018·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Karl FenglerPhilipp Lurz
Jul 18, 2018·Journal of Hypertension·Roland E SchmiederUNKNOWN Members of the ESH Working Group on Interventional Treatment of Hypertension
Sep 12, 2018·Journal of the American Board of Family Medicine : JABFM·Antoinette SchoenthalerLauren Jacobowitz
Mar 29, 2019·Circulation Research·Michel Burnier, Brent M Egan
Apr 4, 2019·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Roland E SchmiederChristian Ott

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Citations

Apr 25, 2020·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Dominic MillenaarFelix Mahfoud

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