DOI: 10.1101/507871Jan 4, 2019Paper

iTALK: an R Package to Characterize and Illustrate Intercellular Communication

BioRxiv : the Preprint Server for Biology
Yuanxin WangLinghua Wang

Abstract

Crosstalk between tumor cells and other cells within the tumor microenvironment (TME) plays a crucial role in tumor progression, metastases, and therapy resistance. We present iTALK, a computational approach to characterize and illustrate intercellular communication signals in the multicellular tumor ecosystem using single-cell RNA sequencing data. iTALK can in principle be used to dissect the complexity, diversity, and dynamics of cell-cell communication from a wide range of cellular processes.

Related Concepts

Neoplasm Metastasis
Tumor Progression
Neoplastic Cell
Sequence Determinations, RNA
Intercellular Communication Process
Cellular Process
Cellular Tumor Suppression
Intercellular Transport

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