Iterative blind deconvolution in magnetic resonance brain perfusion imaging

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Renate Grüner, Torfinn Taxt

Abstract

In first pass magnetic resonance brain perfusion imaging, arterial input functions are used in the deconvolution of the observed contrast concentrations to obtain quantitative hemodynamic parameters. Ideally, arterial input functions should be measured in each imaged voxel to eliminate the effects of delay and dispersion of the contrast agent from the injection site. An approach based on iterative blind deconvolution with the Richardson-Lucy algorithm is proposed for the simultaneous estimation of voxel-specific arterial input functions and voxel-specific tissue residue functions. An extended contrast concentration model was used to separate the first pass bolus from additional recirculation and leakage signals. The extended model was evaluated using in vivo data. Computer simulations examined the feasibility of iterative blind deconvolution in perfusion imaging. Preliminary in vivo results from a patient with fibromuscular dysplasia showed territories with delayed/dispersed arterial input functions that coincided with the location of territories supplied by collateral circulation as described from the complete radiologic examination. Higher flow values and shorter mean transit times compared to conventional methods were obtain...Continue Reading

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Citations

Jun 19, 2014·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Kim MouridsenSune Nørhøj Jespersen
Jun 21, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Lakshminarayan V ChintaBojana Stefanovic
Jan 24, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kelvin K WongGeoffrey S Young
May 13, 2014·Journal of Magnetic Resonance Imaging : JMRI·Mark S ShiroishiMeng Law
May 1, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·John J LeeJoshua S Shimony
Jan 6, 2012·IEEE Transactions on Bio-medical Engineering·Torfinn TaxtRolf K Reed
Mar 14, 2012·IEEE Transactions on Medical Imaging·Timothé BoutelierMakoto Sasaki
Oct 3, 2013·Progress in Nuclear Magnetic Resonance Spectroscopy·Fernando Calamante
Jan 27, 2015·Computers in Biology and Medicine·P M GordalizaJ J Vaquero
Aug 18, 2016·Frontiers in Neurology·Kelvin K WongStephen T C Wong
Sep 24, 2014·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Geon-Ho JahngFernando Calamante
Aug 31, 2007·Journal of Magnetic Resonance Imaging : JMRI·Renate Grüner, Torfinn Taxt

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