Abstract
Optical coherence tomography (OCT) is a non-invasive optical imaging modality capable of high resolution imaging of internal tissue structures. It is widely believed that the high axial resolution in OCT systems requires a wide-bandwidth light source. As a result, often the potential advantages of narrow-bandwidth sources (in terms of cost and/or imaging speed) are understood to come at the cost of significant reduction in imaging resolution. In this paper, we argue that this trade-off between resolution and speed is a shortcoming imposed by the-state-of-the-art A-scan reconstruction algorithm, Fast Fourier Transform, and can be circumvented through use of alternative processing methods. In particular, we investigate the shortcomings of the FFT as well as previously proposed alternatives and demonstrate the first application of an iterative regularized re-weighted l<sub>2</sub> norm method to improve the axial resolution of fast scan rate OCT systems in the narrow-bandwidth imaging conditions. We validate our claims via experimental results generated from a home-built OCT system used to image layered phantom and in vivo data. Our results rely on new, sophisticated signal processing algorithms to generate higher precision (i.e.,...Continue Reading
References
Nov 22, 1991·Science·D HuangC A Puliafito
Aug 10, 2006·Nature Methods·Michael J RustXiaowei Zhuang
Aug 12, 2006·Science·Eric BetzigHarald F Hess
Sep 19, 2006·Biophysical Journal·Samuel T HessMichael D Mason
Nov 17, 2007·Optics Letters·G J TearneyB E Bouma
Dec 26, 2008·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Yiheng LiuXiaonong Zhu
Mar 5, 2007·Optics Express·Dvir YelinGuillermo J Tearney
Oct 14, 2010·Optics Express·Xuan Liu, Jin U Kang
Aug 4, 2012·Optics Letters·Ning ZhangPing Xue
Aug 17, 2012·Journal of Biomedical Optics·Evgenia Bousi, Costas Pitris
Apr 1, 1996·Journal of Biomedical Optics·A F Fercher
Nov 13, 2013·Optics Express·Hee Yoon LeeAudrey K Ellerbee
Mar 14, 2014·Journal of Biomedical Optics·Kristen L LurieAudrey K Ellerbee
Oct 21, 2015·Optics Express·Xinyu LiuLinbo Liu