ITGB4 deficiency in bronchial epithelial cells directs airway inflammation and bipolar disorder-related behavior

Journal of Neuroinflammation
Li HanChi Liu

Abstract

Chronic persistent airway inflammation has been associated with the comorbidity of asthma and bipolar disorder (BD). However, the direct relevance between airway inflammation and BD-like psychiatric comorbidity is almost unknown. Integrin β4 (ITGB4) is downregulated on the airway epithelial of asthma patients, which might play a critical role in the parthenogenesis of airway inflammation. So this study aimed to examine the role of ITGB4 deficiency in mediating airway inflammation and further leading to the BD-like behaviors. ITGB4-/- mice were generated by mating ITGB4fl/fl mice with CCSP-rtTAtg/-/TetO-Cretg/tg mice. Mania-like behavior tests were performed, including hyperlocomotion, D-amphetamine-induced hyperactivity, open-field test, and elevated plus-maze test. Depressive-like behavior tests were carried out, including sucrose preference, forced swimming, and learned helplessness. Inflammatory cells (Th17, Th1, Th2) in the lung were examined by flow cytometry. Futhermore, inflammatory cytokines (IL-4, IL-13) in bronchoalveolar lavage fluid and sera were detected by ELISA. Protein expression of the IL-4Rα on choroid plexus, microglial marker (IBA1), and synapse-associated proteins (synaptophysin, SYP) in the hippocampus and...Continue Reading

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Citations

Oct 11, 2019·International Journal of Environmental Research and Public Health·Tin-Tin Win-ShweHirohisa Takano
May 28, 2019·Frontiers in Cell and Developmental Biology·Oindrila BhattacharjeeSrikala Raghavan
Jun 10, 2021·Brain, Behavior, and Immunity·Emily AllgireRenu Sah

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Methods Mentioned

BETA
GTPases
lavage
bronchoalveolar lavage
flow cytometry
light microscopy
ELISA

Software Mentioned

CellQuest
SPSS
Panlab Samrt

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