ITN protection, MSP1 antibody levels and malaria episodes in young children of rural Burkina Faso

Acta Tropica
Gisela Kynast-WolfOlaf Müller

Abstract

Malaria blood-stage vaccines are in an early phase of clinical development with MSP1 being a major antigen candidate. There are limited data on the protective efficacy of antibodies against subunits of MSP1 in the malaria endemic areas of sub-Saharan Africa. This prospective cohort study was nested into a large insecticide-treated mosquito net (ITN) trial during which neonates were individually randomised to ITN protection from birth vs. protection from month six onwards in rural Burkina Faso. A sub sample of 120 children from three villages was followed for 10 months with six measurements of MSP1(42) antibodies (ELISA based on recombinant 42kDa fragment) and daily assessment of malaria episodes. Time to the next malaria episode was determined in relation to MSP1(42) antibody titres. MSP1(42) antibody titres were dependent on age, season, ITN-group, number of previous malaria episodes and parasitaemia. There were no significant differences in time until the next malaria episode in children with low compared to children with high MSP1(42) antibody titres at any point in time (101 vs. 97 days in May, p=0.6; 58 vs. 84 days in September, p=0.3; 144 vs. 161 days in March, p=0.5). The findings of this study support the short-lived na...Continue Reading

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Citations

Sep 17, 2011·Malaria Journal·Carol A Baume, Ana Cláudia Franca Koh
Jan 5, 2011·Malaria Journal·Georgia B DamienMarie-Claire Henry
Nov 30, 2012·Parasites & Vectors·Humphrey D MazigoDavid W Dunne
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Jun 23, 2009·Malawi Medical Journal : the Journal of Medical Association of Malawi·Dylo F PembaJimmy Namangale

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