ITPA gene polymorphisms significantly affect hemoglobin decline and treatment outcomes in patients coinfected with HIV and HCV.

Journal of Medical Virology
Anu OsinusiShyam Kottilil

Abstract

Published studies have described a strong association with a single-nucleotide polymorphism (SNP) in the inosine triphosphate pyrophosphatase (ITPA) gene and ribavirin (RBV)-induced hemolytic anemia in HCV-infected patients receiving pegylated interferon (pegIFN) and RBV. This study sought to evaluate the effect of these polymorphisms on anemia, hemoglobin reduction, HCV kinetics, and treatment outcomes. Sixty-three patients coinfected with HIV and HCV and 58 patients infected with HCV only were treated with pegIFN/RBV were genotyped using the ABI TaqMan allelic discrimination kit for the 2 ITPA SNP variants rs1127354 and rs7270101. A composite variable of ITPA deficiency using both SNPs was created as previously reported. Statistical analysis was performed using Mann-Whitney test or Chi square/Fishers exact test for categorical data and mixed model analysis for multiple variables. Thirty-five patients (30%) were predicted to have reduced ITPA activity. ITPA deficiency was found to be protective against the development of hemoglobin reduction >3 g/dl over the course of treatment. The rates of hemoglobin reduction >3 g/dl decreased in correlation with the severity of ITPA deficiency. ITPA deficiency was associated with slower he...Continue Reading

Associated Clinical Trials

Jun 28, 2001·Shyamasundaran Kottilil, M.D., Shyamasundaran Kottilil, M.D.

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Citations

Oct 12, 2013·Pharmacotherapy·Marina Kawaguchi-Suzuki, Reginald F Frye
Jun 2, 2016·Pharmacogenomics·Antonio D'AvolioGiovanni Di Perri
Mar 13, 2018·Clinical Orthopaedics and Related Research·Anton Khlopas, Michael A Mont
Jul 12, 2018·Pharmacogenomics·Mario FriasAntonio Rivero

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