Itraconazole: Precautions regarding drug interactions and bioavailability.

The Canadian Journal of Infectious Diseases = Journal Canadien Des Maladies Infectieuses
M P Puttick, P Phillips

Abstract

To describe patients with fungal infections in whom drug interactions and bioavailability problems were associated with itraconazole treatment failure. Retrospective chart review. Two tertiary care university-affiliated teaching hospitals. Itraconazole-treated patients between 1990 and 1992. Four patients treated with itraconazole were identified in whom suboptimal serum itraconazole levels were associated with relapse of disseminated histoplasmosis, treatment failure of invasive aspergillosis or development of superficial mycoses. Low serum itraconazole levels were associated with concurrent therapy with rifampin or agents inhibiting gastric acid secretion, with administration of itraconazole capsule contents through a nasogastric tube or with the presence of aids. It is recommended that serum itraconazole levels be measured in patients with potentially life-threatening mycoses if coexistent factors may interfere with itraconazole therapy.

Citations

Aug 29, 2013·Journal of Veterinary Emergency and Critical Care·Victoria I VorathavornDavid G Feldman
Nov 26, 2005·Scandinavian Journal of Infectious Diseases·Shang-Miao ChangChin-Yin Sheu

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Aspergillosis (ASM)

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Aspergillosis

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

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