Itraconazole suppresses an elicitation phase of a contact hypersensitivity reaction

The Journal of Investigative Dermatology
Urupongsa AusaneyaY Aragane

Abstract

Contact dermatitis is caused by epicutaneous exposure to environmentally and/or industrially derived allergens. As the exposure is unavoidable in many instances, therapeutic suppression of allergic inflammation appears to be of clinical relevance. It was recently reported that itraconazole (ITZ), an anti-fungal agent, may be of therapeutic importance in allergic skin diseases. Therefore, we were interested in the effect of ITZ on contact hypersensitivity (CHS). Mice (C3H/HeN or Balb/c) were administered with ITZ orally before sensitization or challenged with haptens (dinitrofluorobenzene or oxazolone). Consequently, the administration of ITZ before challenge, but not before sensitization, significantly suppressed the reaction. Intriguingly, ITZ failed to suppress the irritant dermatitis induced by croton oil or benzalkonium chloride, suggesting that it may affect molecule(s) rather selectively involved in the elicitation of CHS. To further analyze mechanisms involved, splenic T cells obtained from sensitized or naive mice were stimulated with plate-bound anti-CD3 in the presence or absence of ITZ and release of cytokines was tested by ELISA. T cells from hapten-immunized mice produced a significant amount of IFN-gamma, which wa...Continue Reading

References

Feb 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·A H Enk, S I Katz
Jun 1, 1994·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·J M Zuckerman, A R Tunkel
Sep 1, 1996·The Journal of Allergy and Clinical Immunology·H L KolmerT A Platts-Mills
Jun 2, 1998·Archives of Dermatology·M MiharaT Inoue

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Citations

Oct 25, 2008·American Journal of Respiratory and Critical Care Medicine·David W DenningRobert M Niven
Nov 17, 2009·Respirology : Official Journal of the Asian Pacific Society of Respirology·Alessandro C PasqualottoDavid W Denning
May 25, 2011·Mycoses·Ritesh AgarwalArunaloke Chakrabarti
Feb 24, 2010·The Journal of Dermatology·Yuichiro TsunemiShinichi Sato
Jul 27, 2011·Current Allergy and Asthma Reports·Ritesh Agarwal
Nov 22, 2014·Current Opinion in Pulmonary Medicine·Amit D ParulekarNicola A Hanania
Jul 29, 2010·Medical Mycology·Ritesh Agarwal, Dheeraj Gupta

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