It's ALL in the Family: IKZF1 and Hereditary Leukemia

Cancer Cell
Junne Kamihara, Akiko Shimamura

Abstract

IKZF1 plays an essential role in lymphopoiesis, and somatic IKZF1 variants in acute lymphoblastic leukemia (ALL) are associated with poor prognosis. In this issue of Cancer Cell, Churchman et al. add to the list of leukemia predisposition genes with the identification and characterization of germline IKZF1 variants in childhood ALL.

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