It's time: A commentary on fear extinction in the human brain using fMRI

Neuroscience and Biobehavioral Reviews
Jayne MorrissCarien M van Reekum


The recent meta-analysis by Fullana et al. (2018) is both timely and significant, providing a vital milestone towards understanding the neural networks involved in threat extinction in humans. Fullana et al. (2018) examined both threat extinction and recall separately using sophisticated meta-analytic methods based on raw contrast maps. Importantly, the meta-analysis highlighted a lack of consistent activation across studies for key neural "players" in the threat extinction circuit: the amygdala and ventromedial prefrontal cortex (vmPFC). In the current commentary, we highlight reasons for which this key circuitry may not have resulted from this meta-analysis, and call for a 'gold standard' in the examination of threat extinction using fMRI.


Feb 12, 2020·The European Journal of Neuroscience·Birthe MacdonaldTom Johnstone
Aug 18, 2020·Translational Psychiatry·Josh M CislerClinton D Kilts
May 22, 2021·Behaviour Research and Therapy·Kevin M CrombieJosh M Cisler

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