IV Immunoglobulin for Acute Lung Injury and Bacteremia in Pseudomonas aeruginosa Pneumonia

Critical Care Medicine
Hideya KatohT Sawa

Abstract

Virulent and multidrug-resistant Pseudomonas aeruginosa causes a lethal pneumonia, especially in patients who are artificially ventilated. It has been reported that the virulence mechanism used by P. aeruginosa, which is linked to acute lung injury, is strongly associated with the type III secretion system, and specific antibodies targeting this system have shown a protective effect in both experimental and clinical settings. We investigated the effect of administering IV immunoglobulins on P. aeruginosa pneumonia, including its associated bacteremia and mortality, although focusing especially on type III secretion system-associated P. aeruginosa virulence. Prospective randomized and controlled animal study. University laboratory. Male ICR mice. Mice were infected intratracheally with a lethal dose of the virulent P. aeruginosa PA103 strain. IV immunoglobulin administration was examined in three different settings: 1) premixed; 2) pre-IV, prophylactic administration before bacterial infection; and 3) post-IV, therapeutic administration after bacterial infection. The effect of specific antigen titer depletion of IV immunoglobulins was also examined. Survival and body temperature were monitored for 24 hours. Bacteremia, cytokine ...Continue Reading

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Citations

Dec 24, 2015·Microbiology and Immunology·Hiroaki YasumotoTeiji Sawa
Sep 3, 2016·International Immunopharmacology·Wen-Chung HuangChian-Jiun Liou
Nov 1, 2017·American Journal of Respiratory and Critical Care Medicine·Colleen S CurranParizad Torabi-Parizi
Mar 3, 2018·Journal of Intensive Care·Stefanie ProhaskaHelene A Haeberle
Dec 18, 2015·Critical Care Medicine·Jerome C Crowley, Michael A Gropper
Apr 4, 2017·Microbiology and Immunology·Saeko HamaokaTeiji Sawa

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