I.V. infusion of magnesium sulphate during spinal anaesthesia improves postoperative analgesia

British Journal of Anaesthesia
J-Y HwangS-H Do

Abstract

In a randomized, double-blind, prospective study, we have evaluated the effect of i.v. infusion of magnesium sulphate during spinal anaesthesia on postoperative analgesia and postoperative analgesic requirements. Forty patients undergoing total hip replacement arthroplasty under spinal anaesthesia were included. After the induction of spinal anaesthesia, the magnesium group (Group M) received magnesium sulphate 50 mg kg(-1) for 15 min and then 15 mg kg(-1) h(-1) by continuous i.v. infusion until the end of surgery. The saline group (Group S) received the same volume of isotonic saline over the same period. After surgery, a patient-controlled analgesia (PCA) device containing morphine and ketorolac was provided for the patients. Postoperative pain scores, PCA consumption, and the incidences of shivering, postoperative nausea, and vomiting were evaluated immediately after surgery, and at 30 min, 4, 24, and 48 h after surgery. Serum magnesium concentrations were checked before the induction of anaesthesia, immediately after surgery, and at 1 and 24 h after surgery. Postoperative pain scores were significantly lower in Group M at 4, 24, and 48 h after surgery (P<0.05). Cumulative postoperative PCA consumptions were also significant...Continue Reading

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Citations

May 29, 2012·International Journal of Obstetric Anesthesia·J T SullivanC A Wong
Mar 17, 2010·British Journal of Anaesthesia·K SadacharamS-H Do
Mar 26, 2014·Saudi Journal of Anaesthesia·Akansha AgrawalYashwant S Payal
Oct 21, 2011·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Ae Ryoung LeeSoo Joo Choi
Oct 12, 2012·Journal of Anesthesia·Tsuyoshi SatsumaeMakoto Tanaka
Nov 28, 2012·Journal of Pain and Symptom Management·Vincent CrosbyAndrew Wilcock
Jan 25, 2011·Expert Opinion on Pharmacotherapy·Frances Lui, Kwok-Fu Jacobus Ng
Dec 3, 2014·Revista española de cirugía ortopédica y traumatología·J Díaz-HerediaM Á Ruiz Iban
Jul 21, 2016·Acta Anaesthesiologica Taiwanica : Official Journal of the Taiwan Society of Anesthesiologists·Prerana N Shah, Yamini Dhengle
Mar 24, 2017·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Sedigheh NadriMahmoud Reza Moradkhani
Mar 2, 2012·Acta Cirúrgica Brasileira·Rafael DeRossiFabrício Oliveira Frazílio
Nov 26, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Magdalena Bujalska-ZadrożnyMarek Naruszewicz
Aug 2, 2013·Korean journal of anesthesiology·Sang-Hwan Do
Mar 3, 2011·Anesthesiology·Susanne HerroederMarkus W Hollmann
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May 21, 2019·Frontiers in Pharmacology·Ismar Lima CavalcantiNubia Verçosa
Jul 29, 2020·Nutrients·Hyun-Jung ShinSang-Hwan Do
Mar 9, 2021·Journal of Anesthesia·Tetsuzo NakayamaKen Yamaura
May 1, 2021·Nutrients·Véronique MorelGisèle Pickering
Jan 18, 2011·Annales Françaises D'anesthèsie Et De Rèanimation·M S MebazaaM S Ben Ammar

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