Ivabradine as a stabilising anti-arrhythmic agent for multifocal atrial tachycardia.

Cardiology in the Young
Mitchell I CohenLucas Collazo

Abstract

Multifocal atrial tachycardia has certain electrocardiographic similarities to atrial fibrillation. The mechanism of atrial fibrillation is heterogenous but in some cases may arise from a single ectopic driver with fibrillatory conduction to the rest of the atria. This has led to the speculation that multifocal atrial tachycardia may have a similar mechanistic unifocal site that disperses through the atrium in a fibrillatory pattern. Ivabradine has been reported to be efficacious in an adult with paroxysmal atrial fibrillation as well as in children with junctional or ectopic atrial tachycardias. This is the first report of successfully using ivabradine, a novel anti-arrhythmic If blocking agent, to convert multifocal atrial tachycardia in a 5-month-old critically ill infant to a pattern indicating a single ectopic atrial focus. This allowed the patient's single atrial focus to be ablated with return to sinus rhythm and decannulation from ventriculoarterial extracorporeal membrane oxygenation. This case suggests that multifocal atrial tachycardia may arise from a single automatic focus with downstream fibrillatory conduction to the atria.

References

May 29, 2000·Journal of Cardiovascular Electrophysiology·L M BevilacquaJ K Triedman
Aug 14, 2001·Journal of the American College of Cardiology·D J BradleyM Dick
Nov 16, 2011·Circulation·Yu-ki IwasakiStanley Nattel
Dec 8, 2011·Circulation. Arrhythmia and Electrophysiology·Leonardo CalòErnesto Lioy
May 25, 2016·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Jana-Katharina DieksUlrich Krause
Sep 2, 2017·Journal of the American College of Cardiology·Damien BonnetPiers E F Daubeney
Feb 15, 2018·Korean Circulation Journal·Seung Min BaekChung Il Noh
Jul 10, 2019·HeartRhythm Case Reports·Christopher M JansonMaully J Shah

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Citations

Aug 21, 2021·Frontiers in Cardiovascular Medicine·Nour K YounisMariam Arabi

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