Ivermectin: a systematic review from antiviral effects to COVID-19 complementary regimen.

The Journal of Antibiotics
Fatemeh Heidary, Reza Gharebaghi

Abstract

Ivermectin proposes many potentials effects to treat a range of diseases, with its antimicrobial, antiviral, and anti-cancer properties as a wonder drug. It is highly effective against many microorganisms including some viruses. In this comprehensive systematic review, antiviral effects of ivermectin are summarized including in vitro and in vivo studies over the past 50 years. Several studies reported antiviral effects of ivermectin on RNA viruses such as Zika, dengue, yellow fever, West Nile, Hendra, Newcastle, Venezuelan equine encephalitis, chikungunya, Semliki Forest, Sindbis, Avian influenza A, Porcine Reproductive and Respiratory Syndrome, Human immunodeficiency virus type 1, and severe acute respiratory syndrome coronavirus 2. Furthermore, there are some studies showing antiviral effects of ivermectin against DNA viruses such as Equine herpes type 1, BK polyomavirus, pseudorabies, porcine circovirus 2, and bovine herpesvirus 1. Ivermectin plays a role in several biological mechanisms, therefore it could serve as a potential candidate in the treatment of a wide range of viruses including COVID-19 as well as other types of positive-sense single-stranded RNA viruses. In vivo studies of animal models revealed a broad range o...Continue Reading

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Citations

Aug 23, 2020·Nanomaterials·Sangiliyandi GurunathanHyuk Song
Sep 10, 2020·Expert Review of Clinical Immunology·Fatemeh Heidary, Reza Gharebaghi
Sep 26, 2020·Frontiers in Public Health·Maria Laura IddaMatteo Floris
Oct 13, 2020·Frontiers in Medicine·Amélia Carolina Lopes FernandesEduardo Pereira de Azevedo
Nov 6, 2020·Expert Opinion on Investigational Drugs·Maricar MalinisJeffrey Topal
Oct 20, 2020·Journal of Medical Virology·Charles W StrattonHongzhou Lu
Nov 27, 2020·Microorganisms·Souvik Ghosh, Yashpal S Malik
Jan 5, 2021·Frontiers in Pharmacology·Bruno Silva AndradeVasco Ariston de Carvalho Azevedo
Nov 1, 2020·Drug Discovery Today·Jose J NavejaKarina Martinez-Mayorga
Nov 19, 2020·Minerva medica·Jessica Cusato
Jan 22, 2021·Communications Biology·Vicky ModyShashidharamurthy Taval
Jan 3, 2021·The International Journal of Risk & Safety in Medicine·Kavita ManchandaHarmanjit Singh
Dec 2, 2020·International Journal of Antimicrobial Agents·Martin D Hellwig, Anabela Maia
Mar 2, 2021·Journal of Infection and Public Health·Marwan ElBagouryAmy Hutchinson
Mar 9, 2021·Advanced Nanobiomed Research·Halle LutzKe Cheng
Nov 2, 2020·Clinical & Experimental Ophthalmology·Camilo Brandão-de-ResendeDaniel Vitor Vasconcelos-Santos
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Feb 13, 2021·AIMS Public Health·Srikanth UmakanthanMaryann Bukelo
May 6, 2021·BMC Infectious Diseases·Nurullah OkumuşGürhan Taşkın
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