PMID: 2095348Jan 1, 1990Paper

Ivermectin binds avidly to plasma proteins

European Journal of Clinical Pharmacology
U KlotzP O Okonkwo

Abstract

Human pharmacokinetic data on the new anti-parasitic agent, ivermectin, are scanty. For the evaluation of its disposition a specific HPLC assay with sensitive fluorescence detection was developed. Applying equilibrium dialysis, plasma protein binding of ivermectin was measured in five healthy individuals and it averaged 93.2 +/- 4.4% (SD). Such strong binding should be taken into consideration, especially in patients with malnutrition or with diseases in which a decrease in plasma proteins and consequently a higher free fraction of ivermectin could be expected.

References

Jan 1, 1988·European Journal of Clinical Pharmacology·G EdwardsA M Breckenridge

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Citations

May 1, 1992·Transactions of the Royal Society of Tropical Medicine and Hygiene·C P Chijioke, P O Okonkwo
Jun 7, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Francisco M MartyLindsey R Baden
Jun 4, 2010·Vector Borne and Zoonotic Diseases·Hanafi A HanafiDavid F Hoel
Oct 1, 1996·Journal of Veterinary Pharmacology and Therapeutics·Q A McKellar, H A Benchaoui
May 1, 2008·The AAPS Journal·Aránzazu González CangaJuan J García Vieitez
Jul 17, 2008·Journal of the American Veterinary Medical Association·Patrick J KennyDavid J Maggs
May 22, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Gökhan EraslanSule Altinordulu
Nov 13, 2004·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Mohamad Firas BassissiAnne Lespine
Jan 21, 2010·Scandinavian Journal of Infectious Diseases·Jonathan D GreinLawrence Fleckenstein
May 8, 2020·Clinical Pharmacology and Therapeutics·Virginia D SchmithLauren R L Lohmer
May 29, 2020·Naunyn-Schmiedeberg's Archives of Pharmacology·Emanuele Rizzo
Mar 30, 2021·Frontiers in Pharmacology·Charlotte KernFelix Hammann
Jun 16, 2021·The Journal of Antibiotics·Asiya Kamber Zaidi, Puya Dehgani-Mobaraki
Dec 20, 1999·Journal of Agricultural and Food Chemistry·K AsbakkA Oksanen

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