PMID: 9171850Apr 1, 1997Paper

Ivermectin for the chemotherapy of bancroftian filariasis: a meta-analysis of the effect of single treatment

Tropical Medicine & International Health : TM & IH
W C CaoJ D Habbema

Abstract

The efficacy and safety of ivermectin in the treatment of filariasis due to Wuchereria bancrofti was assessed by a meta-analysis of the results from 15 published clinical trials. Seven hundred and forty-eight microfilaraemic patients were enrolled in 7 dose-finding and 8 comparative studies. Administered as a single dose, ivermectin induced nearly complete clearance of microfilariae from the blood from the first day to 30 days post-treatment, followed by gradual recurrence of microfilaraemia and increase in its intensity. Higher doses of ivermectin showed greater clearance effects and maintained lower microfilaraemia levels for a longer time. The adverse reactions caused by the drug were flu-like, transient, generally mild and well tolerated by patients. The frequency and intensity of adverse reactions were strongly associated with pretreatment microfilaria counts in the blood, but independent of dose. The findings of the meta-analysis suggest that ivermectin given at a single annual dose of 200 micrograms/kg body weight or higher, whether or not in combination with DEC, has great potential for therapeutic strategies to control bancroftian filariasis.

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Citations

Aug 6, 1998·Transactions of the Royal Society of Tropical Medicine and Hygiene·D W Meyrowitsch, P E Simonsen
Dec 29, 2000·Transactions of the Royal Society of Tropical Medicine and Hygiene·D W MeyrowitschP Magnussen
Jul 29, 2016·Pathogens and Disease·Sweta MisraShailja Misra-Bhattacharya
Feb 24, 2001·Transactions of the Royal Society of Tropical Medicine and Hygiene·D H MolyneuxD Heymann
Jun 10, 2004·Transactions of the Royal Society of Tropical Medicine and Hygiene·Paul E SimonsenEdwin Michael
Oct 20, 2005·The Cochrane Database of Systematic Reviews·Julia CritchleyUNKNOWN International Filariasis Review Group
Apr 14, 2004·Tropical Medicine & International Health : TM & IH·James M Tielsch, Arlyne Beeche
Jun 12, 2002·Transactions of the Royal Society of Tropical Medicine and Hygiene·Samuel K Dunyo, Paul E Simonsen
Jul 1, 2017·PLoS Neglected Tropical Diseases·Hugues C Nana-DjeungaJoseph Kamgno
Jan 9, 2019·The Cochrane Database of Systematic Reviews·Cara L MacfarlanePaul Garner
Dec 29, 2000·Transactions of the Royal Society of Tropical Medicine and Hygiene·J O Gyapong
Mar 13, 2003·Annals of Tropical Medicine and Parasitology·D H Molyneux, N Zagaria
Jun 20, 2000·Parasitology Today·A P PlaisierJ D Habbema
Jun 22, 2002·International Journal for Parasitology·Wayne D Melrose
Jul 29, 2005·The Lancet Infectious Diseases·Daniel J TischJames W Kazura

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