Abstract
The use of pyrethroids to control the human head louse, Pediculus humanus capitis De Geer (Anoplura: Pediculidae), has suffered considerable loss of efficacy due to the evolution of resistance. Thus, the development of efficiently insecticide delivery systems is imperative for the control of head lice. We studied the insecticidal activity of ivermectin-loaded lipid nanocapsules (IVM-LNC) against permethrin-resistant head lice from Argentina. The LNC, prepared by a phase inversion procedure, were characterized in terms of size, surface potential, and physical stability. These nanoparticles were nearly spherical with mean diameters of 55 nm and narrow size distribution (PI ≤ 0.2). The KT50 mortality values of head lice after exposure to two IVM-LNC formulations (0.11 and 0.28%) were significantly smaller (5 and 3 h, respectively) compared to those exposed only to LNC control group (8 h). This investigation showed the effectiveness in the encapsulation of ivermectin (IVM) into stable LNC dispersion with a potential clinical activity against head lice.
References
Apr 1, 1995·International Journal for Parasitology·J H GillE Lacey
Nov 22, 1997·Parasitology·D J BrownleeR J Walker
Oct 17, 1998·Journal of Medical Entomology·M I PicolloE N Zerba
Jun 14, 2002·Journal of Medical Entomology·G Mougabure CuetoE N Zerba
Jul 24, 2002·Pharmaceutical Research·Béatrice HeurtaultJean-Pierre Benoit
Dec 4, 2003·Annual Review of Entomology·Ian F Burgess
Nov 11, 2008·International Journal of Pharmaceutics·Jana PardeikeRainer H Müller
Jan 17, 2009·Parasitology Research·Ariel TolozaMaría Inés Picollo
Feb 27, 2009·Parasitology Research·A GallardoM I Picollo
Mar 14, 2009·Current Opinion in Infectious Diseases·Ian F Burgess
May 5, 2009·International Journal of Pharmaceutics·N T HuynhJ P Benoit
Feb 12, 2010·Environmental Entomology·Jim M StoryLinda J White
Mar 12, 2010·The New England Journal of Medicine·Olivier ChosidowIan Burgess
Dec 9, 2010·Pediatric Dermatology·Marian J CurrieFrancis J Bowden
Dec 22, 2010·Archives of Dermatological Research·Paola Gonzalez-AudinoGastón Mougabure-Cueto
Oct 11, 2011·Parasitology Research·Anabella GallardoAriel Ceferino Toloza
Jan 14, 2012·Journal of Medical Entomology·Joseph P StrycharzJ Marshall Clark
Jan 3, 2013·International Journal of Dermatology·Terri L MeinkingMargie Bell
Mar 13, 2014·Journal of Medical Entomology·Ariel Ceferino TolozaMaría Inés Picollo
Aug 8, 2014·BioMed Research International·Chiara DianzaniGiuseppina Barrera
Feb 27, 2015·Parasitology Research·Catherine Combescot-LangKosta Y Mumcuoglu
Feb 8, 2016·Parasitology Research·G V Ullio GamboaD A Allemandi
Jun 16, 2016·Journal of Pain & Palliative Care Pharmacotherapy· Food And Drug Administration Public Health Service U S Department Of Health And Human Services