IVF affects embryonic development in a sex-biased manner in mice

Reproduction : the Official Journal of the Society for the Study of Fertility
Kun TanJianhui Tian

Abstract

Increasing evidence indicates that IVF (IVF includes in vitro fertilization and culture) embryos and babies are associated with a series of health complications, and some of them show sex-dimorphic patterns. Therefore, we hypothesized that IVF procedures have sex-biased or even sex-specific effects on embryonic and fetal development. Here, we demonstrate that IVF-induced side effects show significant sexual dimorphic patterns from the pre-implantation to the prenatal stage. During the pre-implantation stage, female IVF embryos appear to be more vulnerable to IVF-induced effects, including an increased percentage of apoptosis (7.22 ± 1.94 vs 0.71 ± 0.76, P<0.01), and dysregulated expression of representative sex-dimorphic genes (Xist, Hprt, Pgk1 and Hsp70). During the mid-gestation stage, IVF males had a higher survival rate than IVF females at E13.5 (male:female=1.33:1), accompanied with a female-biased pregnancy loss. In addition, while both IVF males and females had reduced placental vasculogenesis/angiogenesis, the compensatory placental overgrowth was more evident in IVF males. During the late-gestation period, IVF fetuses had a higher sex ratio (male:female=1.48:1) at E19.5, and both male and female IVF placentas showed ov...Continue Reading

References

Aug 16, 2016·Fertility and Sterility·Lisa A VroomanMarisa S Bartolomei
Apr 19, 2017·Journal of Developmental Origins of Health and Disease·Sky Feuer, Paolo Rinaudo
Feb 20, 2018·Molecular Reproduction and Development·Veronique Duranthon, Pascale Chavatte-Palmer
Oct 17, 2017·Reproduction : the Official Journal of the Society for the Study of Fertility·Serafín Pérez-CerezalesA Gutierrez-Adan
Nov 18, 2018·Molecular Human Reproduction·Ludmila A GerlinskayaMikhail P Moshkin
May 17, 2019·Molecular Reproduction and Development·Qing ZhouKarsten Kristiansen
May 20, 2017·Biology of Sex Differences·Jacinta I Kalisch-SmithK M Moritz
Feb 19, 2020·Annual Review of Animal Biosciences·Peter J Hansen
May 10, 2020·Animals : an Open Access Journal From MDPI·Ximo Garcia-DominguezFrancisco Marco-Jiménez

Citations

Aug 4, 1990·BMJ : British Medical Journal·D J BarkerS J Simmonds
Jun 1, 1996·Archives of Disease in Childhood·V M MooreJ S Robinson
Dec 12, 1997·Molecular Human Reproduction·K Hardy
Jun 17, 1998·Proceedings of the National Academy of Sciences of the United States of America·J M RosensteinJ M Krum
Dec 1, 2001·Human Reproduction·K LundinT Hardarson
Feb 9, 2002·Reproduction, Fertility, and Development·A Gutierrez-AdanJ De La Fuente
Apr 4, 2003·Proceedings of the National Academy of Sciences of the United States of America·C S RosenfeldR M Roberts
Nov 30, 2004·Human Reproduction·Michèle HansenJennifer J Kurinczuk
Jul 22, 2005·Birth Defects Research. Part C, Embryo Today : Reviews·Philippe Arnaud, Robert Feil
Dec 21, 2005·Proceedings of the National Academy of Sciences of the United States of America·M ConstânciaA Fowden
Feb 4, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Aleksey Yevtodiyenko, Jennifer V Schmidt
May 1, 1991·Theriogenology·B AveryT Greve
Sep 21, 2006·Reproduction in Domestic Animals = Zuchthygiene·A Gutierrez-AdanD Rizos
Sep 30, 2006·Fertility and Sterility·Paolo RinaudoRichard M Schultz
Jul 21, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·Gnanaratnam GiritharanPaolo Rinaudo
Nov 8, 2007·Physiological Genomics·P Bermejo-ÁlvarezA Gutierrez-Adan
Jan 1, 2008·Fertility and Sterility·Manon CeelenHenriette A Delemarre-van de Waal
Nov 20, 2008·Reproduction : the Official Journal of the Society for the Study of Fertility·R Fernandez-GonzalezA Gutierrez-Adan
Oct 31, 2009·The International Journal of Developmental Biology·Michelle Desforges, Colin P Sibley
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·P Bermejo-ÁlvarezA Gutierrez-Adan
Apr 7, 2010·The Journal of Clinical Investigation·Katie Cockburn, Janet Rossant
May 27, 2010·Molecular Human Reproduction·David K GardnerGeorge A Thouas
Feb 23, 2011·Reproduction : the Official Journal of the Society for the Study of Fertility·P Bermejo-ÁlvarezA Gutierrez-Adan
May 9, 2012·Endocrinology·Enrrico BloisePaolo Rinaudo
Dec 19, 2012·Reproduction, Fertility, and Development·R Laguna-BarrazaA Gutierrez-Adan
Mar 19, 2013·Cell·Jeannie T Lee, Marisa S Bartolomei
Nov 10, 2013·Birth Defects Research. Part C, Embryo Today : Reviews·Sky Feuer, Paolo Rinaudo
Mar 8, 2014·Fertility and Sterility·Walid E MaaloufIan C W Hardy

Related Concepts

Fertility
Embryo
Study
In Vivo
Cell Growth Pattern
Patterns
Heat-Shock Proteins 70
Angiogenic Process
Placenta Disorders
Vasculogenesis

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis