IVF/ICSI outcomes of the OCP plus GnRH agonist protocol versus the OCP plus GnRH antagonist fixed protocol in women with PCOS: a randomized trial

Archives of Gynecology and Obstetrics
Bulent HaydardedeogluHulusi Bulent Zeyneloglu

Abstract

To compare the IVF/ICSI outcomes of the long GnRH agonist and the fixed GnRH antagonist protocol in women with PCOS. Randomized controlled trial. Baskent University Department of Obstetrics and Gynecology. Three hundred women with PCOS. IVF/ICSI following the long GnRH agonist down-regulation or the fixed GnRH antagonist protocols. Ongoing pregnancy rates. Ongoing pregnancy rates were 36.4 % in the OCP + GnRH agonist group and 35.9 % in the OCP + GnRH antagonist group (p > 0.05). Progesterone levels on the day of hCG (0.76 ± 0.71 vs. 0.58 ± 0.50), endometrial thickness on the day of hCG (11.57 ± 2.50 vs. 10.50 ± 2.01), total gonadotropin used (1388.71 ± 482.39 vs. 1253.25 ± 415.81), and duration of COH (9.07 ± 1.96 vs. 8.39 ± 1.75) were significantly lower in the OCP + GnRH antagonist group. The OCP + long GnRH agonist and the OCP + fixed GnRH antagonist protocols yield similar ongoing pregnancy rates in women with PCOS. Although this study consisting three hundred patients, seems to be large enough in a single center, we were not able to reach to the actual size of power analysis which was approximately 3,000.

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Citations

May 21, 2013·The Journal of Steroid Biochemistry and Molecular Biology·V SobotkaJ Heracek
May 23, 2015·Expert Opinion on Pharmacotherapy·Morena Luigia RoccaMichele Morelli
Oct 28, 2016·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·M KollmannN Raine-Fenning
Apr 30, 2016·The Cochrane Database of Systematic Reviews·Hesham G Al-InanyFrank J Broekmans
Oct 12, 2018·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Zhihui XuHaiyan Yang
May 13, 2021·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Jie LiWeiwei Luo

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